Association between SNP rs13376333 and rs1131820 in the KCNN3 gene and atrial fibrillation in the Chinese Han population

被引：14

作者：

Luo, Zhurong ^{[1
]}

Yan, Chenghui ^{[2
]}

Zhang, Wenli ^{[1
]}

Shen, Xiaoli ^{[3
]}

Zheng, Weixing ^{[1
]}

Chen, Fengping ^{[1
]}

Cao, Xiaozhi ^{[1
]}

Yang, Yuhui ^{[1
]}

Lin, Xianliang ^{[1
]}

Wang, Zhiqing ^{[1
]}

Huang, Mingfang ^{[1
]}

机构：

[1] Xiamen Univ, Fuzhou Gen Hosp, Dept Cardiol, Fuzhou 350025, Peoples R China

[2] Shenyang Gen Hosp, Dept Cardiol, Shenyang, Peoples R China

[3] Fujian Key Lab Cardiovasc Dis, Fuzhou, Peoples R China

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2014年 / 52卷 / 12期

关键词：

atrial fibrillation; KCNN3; polymorphism; RISK-FACTORS; LONE; VARIANTS; CHANNEL; SK3; MANAGEMENT; STROKE; IMPACT; ZFHX3; LOCI;

D O I：

10.1515/cclm-2014-0491

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The small conductance calcium-activated potassium, subfamily N, member 3 (KCNN3) gene rs13376333 and rs1131820 have been shown to be strongly associated with lone atrial fibrillation (AF), while replication association studies between rs13376333 in KCNN3 gene and risk of AF showed conflicting results. The current study tried to validate the impact of SNP rs13376333 and rs1131820 of KCNN3 gene on the risk of AF in the Chinese Han population. Methods: A total of 889 AF patients and 1015 controls were enrolled. Two hundred and seventy-eight cases of AF were lone AF. KCNN3 gene SNP rs13376333 and rs1131820 were genotyped by allele-specific MALDI-TOF mass spectrometry. Results: The genotype distribution and allele frequency of rs13376333 polymorphism were not different between total AF patients and controls. However, the genotype distribution of rs13376333 polymorphism was significantly different between lone AF and control group (p<0.001); and T allele frequency was significantly higher in lone AF group than that in controls (7.6% vs 3.6%, p<0.001). Multivariable logistic regression analysis showed that T allele carriers of rs13376333 was significantly associated with lone AF (OR=2.31, 95% CI 1.41-3.78, p=0.001). No relationship between rs1131820 polymorphism and total AF or lone AF was found in this study. Conclusions: KCNN3 rs13376333 polymorphism was associated with lone AF in the Chinese Han population and the T allele carriers may be an independent predictive factor for lone AF.

引用

页码：1867 / 1873

页数：7

共 30 条

[1] Familial aggregation of atrial fibrillation in Iceland [J].

Arnar, DO ;

Thorvaldsson, S ;

Manolio, TA ;

Thorgeirsson, G ;

Kristjansson, K ;

Hakonarson, H ;

Stefansson, K .

EUROPEAN HEART JOURNAL, 2006, 27 (06) :708-712

[2] Impact of atrial fibrillation on the risk of death [J].

Benjamin, EJ ;

Wolf, PA ;

D'Agostino, RB ;

Silbershatz, H ;

Kannel, WB ;

Levy, D .

CIRCULATION, 1998, 98 (10) :946-952

[3] INDEPENDENT RISK-FACTORS FOR ATRIAL-FIBRILLATION IN A POPULATION-BASED COHORT - THE FRAMINGHAM HEART-STUDY [J].

BENJAMIN, EJ ;

LEVY, D ;

VAZIRI, SM ;

DAGOSTINO, RB ;

BELANGER, AJ ;

WOLF, PA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1994, 271 (11) :840-844

[4] Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry [J].

Benjamin, Emelia J. ;

Rice, Kenneth M. ;

Arking, Dan E. ;

Pfeufer, Arne ;

van Noord, Charlotte ;

Smith, Albert V. ;

Schnabel, Renate B. ;

Bis, Joshua C. ;

Boerwinkle, Eric ;

Sinner, Moritz F. ;

Dehghan, Abbas ;

Lubitz, Steven A. ;

D'Agostino, Ralph B., Sr. ;

Lumley, Thomas ;

Ehret, Georg B. ;

Heeringa, Jan ;

Aspelund, Thor ;

Newton-Cheh, Christopher ;

Larson, Martin G. ;

Marciante, Kristin D. ;

Soliman, Elsayed Z. ;

Rivadeneira, Fernando ;

Wang, Thomas J. ;

Eiriksdottir, Gudny ;

Levy, Daniel ;

Psaty, Bruce M. ;

Li, Man ;

Chamberlain, Alanna M. ;

Hofman, Albert ;

Vasan, Ramachandran S. ;

Harris, Tamara B. ;

Rotter, Jerome I. ;

Kao, W. H. Linda ;

Agarwal, Sunil K. ;

Stricker, Bruno H. Ch ;

Wang, Ke ;

Launer, Lenore J. ;

Smith, Nicholas L. ;

Chakravarti, Aravinda ;

Uitterlinden, Andre G. ;

Wolf, Philip A. ;

Sotoodehnia, Nona ;

Koettgen, Anna ;

van Duijn, Cornelia M. ;

Meitinger, Thomas ;

Mueller, Martina ;

Perz, Siegfried ;

Steinbeck, Gerhard ;

Wichmann, H-Erich ;

Lunetta, Kathryn L. .

NATURE GENETICS, 2009, 41 (08) :879-881

[5] Significant Association of rs13376333 in KCNN3 on Chromosome 1q21 With Atrial Fibrillation in a Taiwanese Population [J].

Chang, Shu-Hsuan ;

Chang, Sheng-Nan ;

Hwang, Juey-Jen ;

Chiang, Fu-Tien ;

Tseng, Chuen-Den ;

Lee, Jen-Kuang ;

Lai, Ling-Ping ;

Lin, Jiunn-Lee ;

Wu, Cho-Kai ;

Tsai, Chia-Ti .

CIRCULATION JOURNAL, 2012, 76 (01) :184-188

[6] Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation [J].

De Jong, Anne Margreet ;

Maass, Alexander H. ;

Oberdorf-Maass, Silke U. ;

Van Veldhuisen, Dirk J. ;

Van Gilst, Wiek H. ;

Van Gelder, Isabelle C. .

CARDIOVASCULAR RESEARCH, 2011, 89 (04) :754-765

[7] Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders [J].

den Hoed, Marcel ;

Eijgelsheim, Mark ;

Esko, Tonu ;

Brundel, Bianca J. J. M. ;

Peal, David S. ;

Evans, David M. ;

Nolte, Ilja M. ;

Segre, Ayellet V. ;

Holm, Hilma ;

Handsaker, Robert E. ;

Westra, Harm-Jan ;

Johnson, Toby ;

Isaacs, Aaron ;

Yang, Jian ;

Lundby, Alicia ;

Zhao, Jing Hua ;

Kim, Young Jin ;

Go, Min Jin ;

Almgren, Peter ;

Bochud, Murielle ;

Boucher, Gabrielle ;

Cornelis, Marilyn C. ;

Gudbjartsson, Daniel ;

Hadley, David ;

van der Harst, Pim ;

Hayward, Caroline ;

den Heijer, Martin ;

Igl, Wilmar ;

Jackson, Anne U. ;

Kutalik, Zoltan ;

Luan, Jian'an ;

Kemp, John P. ;

Kristiansson, Kati ;

Ladenvall, Claes ;

Lorentzon, Mattias ;

Montasser, May E. ;

Njajou, Omer T. ;

O'Reilly, Paul F. ;

Padmanabhan, Sandosh ;

Pourcain, Beate St. ;

Rankinen, Tuomo ;

Salo, Perttu ;

Tanaka, Toshiko ;

Timpson, Nicholas J. ;

Vitart, Veronique ;

Waite, Lindsay ;

Wheeler, William ;

Zhang, Weihua ;

Draisma, Harmen H. M. ;

Feitosa, Mary F. .

NATURE GENETICS, 2013, 45 (06) :621-+

[8] Effects on Atrial Fibrillation in Aged Hypertensive Rats by Ca2+-Activated K+ Channel Inhibition [J].

Diness, Jonas G. ;

Skibsbye, Lasse ;

Jespersen, Thomas ;

Bartels, Emil D. ;

Sorensen, Ulrik S. ;

Hansen, Rie S. ;

Grunnet, Morten .

HYPERTENSION, 2011, 57 (06) :1129-U195

[9] Meta-analysis identifies six new susceptibility loci for atrial fibrillation [J].

Ellinor, Patrick T. ;

Lunetta, Kathryn L. ;

Albert, Christine M. ;

Glazer, Nicole L. ;

Ritchie, Marylyn D. ;

Smith, Albert V. ;

Arking, Dan E. ;

Mueller-Nurasyid, Martina ;

Krijthe, Bouwe P. ;

Lubitz, Steven A. ;

Bis, Joshua C. ;

Chung, Mina K. ;

Doerr, Marcus ;

Ozaki, Kouichi ;

Roberts, Jason D. ;

Smith, J. Gustav ;

Pfeufer, Arne ;

Sinner, Moritz F. ;

Lohman, Kurt ;

Ding, Jingzhong ;

Smith, Nicholas L. ;

Smith, Jonathan D. ;

Rienstra, Michiel ;

Rice, Kenneth M. ;

Van Wagoner, David R. ;

Magnani, Jared W. ;

Wakili, Reza ;

Clauss, Sebastian ;

Rotter, Jerome I. ;

Steinbeck, Gerhard ;

Launer, Lenore J. ;

Davies, Robert W. ;

Borkovich, Matthew ;

Harris, Tamara B. ;

Lin, Honghuang ;

Voelker, Uwe ;

Voelzke, Henry ;

Milan, David J. ;

Hofman, Albert ;

Boerwinkle, Eric ;

Chen, Lin Y. ;

Soliman, Elsayed Z. ;

Voight, Benjamin F. ;

Li, Guo ;

Chakravarti, Aravinda ;

Kubo, Michiaki ;

Tedrow, Usha B. ;

Rose, Lynda M. ;

Ridker, Paul M. ;

Conen, David .

NATURE GENETICS, 2012, 44 (06) :670-U88

[10] Common variants in KCNN3 are associated with lone atrial fibrillation [J].

Ellinor, Patrick T. ;

Lunetta, Kathryn L. ;

Glazer, Nicole L. ;

Pfeufer, Arne ;

Alonso, Alvaro ;

Chung, Mina K. ;

Sinner, Moritz F. ;

de Bakker, Paul I. W. ;

Mueller, Martina ;

Lubitz, Steven A. ;

Fox, Ervin ;

Darbar, Dawood ;

Smith, Nicholas L. ;

Smith, Jonathan D. ;

Schnabel, Renate B. ;

Soliman, Elsayed Z. ;

Rice, Kenneth M. ;

Van Wagoner, David R. ;

Beckmann, Britt-M ;

van Noord, Charlotte ;

Wang, Ke ;

Ehret, Georg B. ;

Rotter, Jerome I. ;

Hazen, Stanley L. ;

Steinbeck, Gerhard ;

Smith, Albert V. ;

Launer, Lenore J. ;

Harris, Tamara B. ;

Makino, Seiko ;

Nelis, Mari ;

Milan, David J. ;

Perz, Siegfried ;

Esko, Tonu ;

Koettgen, Anna ;

Moebus, Susanne ;

Newton-Cheh, Christopher ;

Li, Man ;

Moehlenkamp, Stefan ;

Wang, Thomas J. ;

Kao, W. H. Linda ;

Vasan, Ramachandran S. ;

Noethen, Markus M. ;

MacRae, Calum A. ;

Stricker, Bruno H. Ch ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Levy, Daniel ;

Boerwinkle, Eric ;

Metspalu, Andres ;

Topol, Eric J. .

NATURE GENETICS, 2010, 42 (03) :240-U36

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