Comprehensive multivariate correlations between climatic effect, metabolite-profile, antioxidant capacity and antibacterial activity of Brazilian red propolis metabolites during seasonal study

被引：54

作者：

do Nascimento, Ticiano Gomes ^{[1
,2
]}

dos Santos Arruda, Rodolfo Elleson ^{[1
,2
]}

da Cruz Almeida, Erika Tayse ^{[1
,2
]}

dos Santos Oliveira, Jose Marcos ^{[1
,2
]}

Basilio-Junior, Irinaldo Diniz ^{[1
,2
]}

Celerino de Moraes Porto, Isabel Cristina ^{[1
,2
]}

Sabino, Adilson Rodrigues ^{[1
,2
]}

Tonholo, Josealdo ^{[1
,2
]}

Gray, Alexander ^{[3
]}

Ebel, RuAngelie Edrada ^{[3
]}

Clements, Carol ^{[3
]}

Zhang, Tong ^{[3
]}

Watson, David George ^{[3
]}

机构：

[1] Univ Fed Alagoas, Postgrad Program Pharmaceut Sci, Lab Pharmaceut & Food Anal, Inst Pharmaceut Sci, AC Simoes Campus, BR-57072970 Maceio, Alagoas, Brazil

[2] Univ Fed Alagoas, Postgrad Program Nutr, Coll Nutr, AC Simoes Campus, BR-57072970 Maceio, Alagoas, Brazil

[3] Univ Strathclyde, Dept Pharmaceut Sci, Strathclyde Inst Pharm & Biomed Sci, 27 Taylor St, Glasgow G4 0NR, Lanark, Scotland

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

关键词：

CHEMICAL-COMPOSITION; HONEY-BEE; ANTIMICROBIAL ACTIVITY; BOTANICAL ORIGIN; BIOLOGICAL-ACTIVITY; TURKISH PROPOLIS; BENZOPHENONES; CONSTITUENTS; FLAVONOIDS; ELUCIDATION;

D O I：

10.1038/s41598-019-54591-3

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The standardization of apiceutical products like as propolis extracts has been widely debated worldwide and variations in the propolis chemical composition are still very relevant topics for use-standardized of different propolis-type as medication by much of the world's population. The present manuscript discuss important issues related to the climate effect and variations in propolis metabolite-profiling changes, antioxidant capacity and variations of the antibacterial activity of the Brazilian red propolis metabolites using comprehensive multivariate correlations. It was observed the increasing of guttiferones concentrations during the intense drought period and drastic decreasing in rainy period. The climate variation induced the high concentration of flavonoids in rainy period with pronounced dropped in some rainy months. The Pearson's analysis demonstrated correlation between IC50 from DPPH and guttiferones and flavonoids concentrations. The PCA-X and Hotelling T2 test showed outliers during the months with lowest concentrations of formononetin and isoliquiritigenin was observed in antibacterial tests. The PLS-DA, OPLS-DA and VIP analysis demonstrate guttiferone E, guttiferone B, liquiritigenin, naringenin are considered important substances responsible by anti-staphylococcal activity in red propolis composition during the rainy season and drought period, but a synergistic effect with other flavonoids and isoflavonoids are not ruled out.

引用

页数：16

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