BNT162b2 mRNA COVID-19 vaccine induces antibodies of broader cross-reactivity than natural infection, but recognition of mutant viruses is up to 10-fold reduced

被引:22
作者
Chang, Xinyue [1 ,2 ]
Augusto, Gilles Sousa [1 ,2 ,3 ]
Liu, Xuelan [1 ,4 ]
Kundig, Thomas M. [5 ]
Vogel, Monique [1 ,2 ]
Mohsen, Mona O. [1 ,2 ]
Bachmann, Martin F. [1 ,2 ,3 ,4 ]
机构
[1] Univ Bern, Immunol, RIA, Bern, Switzerland
[2] Univ Bern, Dept BioMed Res, Bern, Switzerland
[3] Univ Oxford, Jenner Inst, Ctr Cellular & Mol Physiol CCMP, Nuffield Dept Med, Oxford, England
[4] Anhui Agr Univ, Int Immunol Ctr, Hefei, Peoples R China
[5] Univ Hosp Zurich, Zurich, Switzerland
基金
瑞士国家科学基金会;
关键词
COVID; SARS-CoV; vaccines;
D O I
10.1111/all.14893
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
引用
收藏
页码:2895 / +
页数:4
相关论文
共 6 条
[1]   SARS-CoV-2 structural features may explain limited neutralizing-antibody responses [J].
Bachmann, Martin F. ;
Mohsen, Mona O. ;
Zha, Lisha ;
Vogel, Monique ;
Speiser, Daniel E. .
NPJ VACCINES, 2021, 6 (01)
[2]   Antibody evasion by the P.1 strain of SARS-CoV-2 [J].
Dejnirattisai, Wanwisa ;
Zhou, Daming ;
Supasa, Piyada ;
Liu, Chang ;
Mentzer, Alexander J. ;
Ginn, Helen M. ;
Zhao, Yuguang ;
Duyvesteyn, Helen M. E. ;
Tuekprakhon, Aekkachai ;
Nutalai, Rungtiwa ;
Wang, Beibei ;
Lopez-Camacho, Cesar ;
Slon-Campos, Jose ;
Walter, Thomas S. ;
Skelly, Donal ;
Clemens, Sue Ann Costa ;
Naveca, Felipe Gomes ;
Nascimento, Valdinete ;
Nascimento, Fernanda ;
da Costa, Cristiano Fernandes ;
Resende, Paola Cristina ;
Pauvolid-Correa, Alex ;
Siqueira, Marilda M. ;
Dold, Christina ;
Levin, Robert ;
Dong, Tao ;
Pollard, Andrew J. ;
Knight, Julian C. ;
Crook, Derrick ;
Lambe, Teresa ;
Clutterbuck, Elizabeth ;
Bibi, Sagida ;
Flaxman, Amy ;
Bittaye, Mustapha ;
Belij-Rammerstorfer, Sandra ;
Gilbert, Sarah C. ;
Carroll, Miles W. ;
Klenerman, Paul ;
Barnes, Eleanor ;
Dunachie, Susanna J. ;
Paterson, Neil G. ;
Williams, Mark A. ;
Hall, David R. ;
Hulswit, Ruben J. G. ;
Bowden, Thomas A. ;
Fry, Elizabeth E. ;
Mongkolsapaya, Juthathip ;
Ren, Jingshan ;
Stuart, David, I ;
Screaton, Gavin R. .
CELL, 2021, 184 (11) :2939-+
[3]   Complete Mapping of Mutations to the SARS-CoV-2 Spike Receptor-Binding Domain that Escape Antibody Recognition [J].
Greaney, Allison J. ;
Starr, Tyler N. ;
Gilchuk, Pavlo ;
Zost, Seth J. ;
Binshtein, Elad ;
Loes, Andrea N. ;
Hilton, Sarah K. ;
Huddleston, John ;
Eguia, Rachel ;
Crawford, Katharine H. D. ;
Dingens, Adam S. ;
Nargi, Rachel S. ;
Sutton, Rachel E. ;
Suryadevara, Naveenchandra ;
Rothlauf, Paul W. ;
Liu, Zhuoming ;
Whelan, Sean P. J. ;
Carnahan, Robert H. ;
Crowe, James E., Jr. ;
Bloom, Jesse D. .
CELL HOST & MICROBE, 2021, 29 (01) :44-+
[4]   Characterization of the receptor-binding domain (RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine [J].
Tai, Wanbo ;
He, Lei ;
Zhang, Xiujuan ;
Pu, Jing ;
Voronin, Denis ;
Jiang, Shibo ;
Zhou, Yusen ;
Du, Lanying .
CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 17 (06) :613-620
[5]   The trinity of COVID-19: immunity, inflammation and intervention [J].
Tay, Matthew Zirui ;
Poh, Chek Meng ;
Renia, Laurent ;
MacAry, Paul A. ;
Ng, Lisa F. P. .
NATURE REVIEWS IMMUNOLOGY, 2020, 20 (06) :363-374
[6]  
Xie XP, 2021, NAT MED, V27, DOI [10.1038/s41591-021-01270-4, 10.1101/2021.01.27.427998]