Epigenetic Mechanisms of the Glucocorticoid Receptor

被引：58

作者：

Bartlett, Andrew A. ^{[1
]}

Lapp, Hannah E. ^{[1
]}

Hunter, Richard G. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Psychol, 100 Morrissey Blvd, Boston, MA 02125 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2019年 / 30卷 / 11期

关键词：

HISTONE DEACETYLASE 1; DNA-METHYLATION; GENE ACTIVATION; ACUTE STRESS; MEMORY FORMATION; BINDING-SITES; DENTATE GYRUS; COACTIVATOR; EXPRESSION; TRANSCRIPTION;

D O I：

10.1016/j.tem.2019.07.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The glucocorticoid receptor (GR) has been shown to be important for mediating cellular responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional changes induced by GR are observed across numerous tissues. However, the mechanisms by which GR achieves cell and tissue-specific effects are less clear. Epigenetic mechanisms have been proposed to explain some of these differences as well as some of the lasting, even transgenerational, effects of stress and glucocorticoid action. GR functions in tandem with epigenetic cellular machinery to coordinate transcription and shape chromatin structure. Here, we describe GR interactions with these effectors and how GR acts to reshape the epigenetic landscape in response to the environment.

引用

页码：807 / 818

页数：12

共 80 条

[1] GCN5 and ADA adaptor proteins regulate triiodothyronine/GRIP1 and SRC-1 coactivator-dependent gene activation by the human thyroid hormone receptor [J].

Anafi, M ;

Yang, YF ;

Barlev, NA ;

Govindan, MV ;

Berger, SL ;

Butt, TR ;

Walfish, PG .

MOLECULAR ENDOCRINOLOGY, 2000, 14 (05) :718-732

[2] Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis [J].

Ananthanarayanan, M. ;

Li, Yanfeng ;

Surapureddi, S. ;

Balasubramaniyan, N. ;

Ahn, Jaeyong ;

Goldstein, J. A. ;

Suchy, Frederick J. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2011, 300 (05) :G771-G781

[3] Acute disruption of select steroid receptor coactivators prevents reproductive behavior in rats and unmasks genetic adaptation in knockout mice [J].

Apostolakis, EM ;

Ramamurphy, M ;

Zhou, D ;

Oñate, S ;

O'Malley, BW .

MOLECULAR ENDOCRINOLOGY, 2002, 16 (07) :1511-1523

[4] DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients [J].

Auta, J. ;

Smith, R. C. ;

Dong, E. ;

Tueting, P. ;

Sershen, H. ;

Boules, S. ;

Lajtha, A. ;

Davis, J. ;

Guidotti, A. .

SCHIZOPHRENIA RESEARCH, 2013, 150 (01) :312-318

[5] Transposons, stress and the functions of the deep genome [J].

Bartlett, Andrew A. ;

Hunter, Richard G. .

FRONTIERS IN NEUROENDOCRINOLOGY, 2018, 49 :170-174

[6] G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of Glucocorticoid Receptor target genes [J].

Bittencourt, Danielle ;

Wu, Dai-Ying ;

Jeong, Kwang Won ;

Gerke, Daniel S. ;

Herviou, Laurie ;

Ianculescu, Irina ;

Chodankar, Rajas ;

Siegmund, Kimberly D. ;

Stallcup, Michael R. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (48) :19673-19678

[7] Coactivators enable glucocorticoid receptor recruitment to fine-tune estrogen receptor transcriptional responses [J].

Bolt, Michael J. ;

Stossi, Fabio ;

Newberg, Justin Y. ;

Orjalo, Arturo ;

Johansson, Hans E. ;

Mancini, Michael A. .

NUCLEIC ACIDS RESEARCH, 2013, 41 (07) :4036-4048

[8] Glucocorticoid receptor β and histone deacetylase 1 and 2 expression in the airways of severe asthma [J].

Butler, Claire A. ;

McQuaid, Stephen ;

Taggart, Cliff C. ;

Weldon, Sinead ;

Carter, Richard ;

Skibinski, Grzegorz ;

Warke, Timothy J. ;

Choy, David F. ;

McGarvey, Lorcan P. ;

Bradding, Peter ;

Arron, Joe R. ;

Heaney, Liam G. .

THORAX, 2012, 67 (05) :392-398

[9] Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway [J].

Caelles, C ;

González-Sancho, JM ;

Muñoz, A .

GENES & DEVELOPMENT, 1997, 11 (24) :3351-3364

[10] The role of microRNAs in glucocorticoid action [J].

Clayton, Sally A. ;

Jones, Simon W. ;

Kurowska-Stolarska, Mariola ;

Clark, Andrew R. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (06) :1865-1874

← 1 2 3 4 5 6 7 8 →