Lesion size and shape in central vein sign assessment for multiple sclerosis diagnosis: An in vivo and postmortem MRI study

被引：8

作者：

Al-Louzi, Omar ^{[1
,2
]}

Manukyan, Sargis ^{[1
,2
]}

Donadieu, Maxime ^{[2
]}

Absinta, Martina ^{[2
,3
,4
,5
]}

Letchuman, Vijay ^{[2
]}

Calabresi, Brent ^{[2
]}

Desai, Parth ^{[6
]}

Beck, Erin S. ^{[2
,7
]}

Roy, Snehashis ^{[8
]}

Ohayon, Joan ^{[9
]}

Pham, Dzung L. ^{[10
]}

Thomas, Anish ^{[6
]}

Jacobson, Steven ^{[11
]}

Cortese, Irene ^{[9
]}

Auluck, Pavan K. ^{[12
]}

Nair, Govind ^{[2
]}

Sati, Pascal ^{[1
,2
]}

Reich, Daniel S. ^{[2
]}

机构：

[1] Cedars Sinai Med Ctr, Dept Neurol, 127 S San Vicente Blvd A6600, Los Angeles, CA 90048 USA

[2] NINDS, Translat Neuroradiol Sect, 10 Ctr Dr MSC 1400,Bldg 10 Room 5C103, Bethesda, MD 20892 USA

[3] Johns Hopkins Sch Med, Dept Neurol, Baltimore, MD USA

[4] IRCCS San Raffaele Hosp, Milan, Italy

[5] Univ Vita Salute San Raffaele, Milan, Italy

[6] NCI, Dev Therapeut Branch, Ctr Canc Res, Bethesda, MD 20892 USA

[7] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA

[8] NIMH, Sect Neural Funct, Bethesda, MD 20892 USA

[9] NINDS, Neuroimmunol Clin, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[10] Henry M Jackson Fdn Adv Mil Med, Ctr Neurosci & Regenerat Med, Bethesda, MD USA

[11] NINDS, Viral Immunol Sect, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[12] NIMH, Human Brain Collect Core, Bethesda, MD 20892 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2022年 / 28卷 / 12期

关键词：

Biomarkers; multiple sclerosis; magnetic resonance imaging; post mortem; T2; lesions; central vein sign; FLAIR-ASTERISK; BRAIN-LESIONS; MS LESIONS; CRITERIA; MAGNIMS; DIFFERENTIATION;

D O I：

10.1177/13524585221097560

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The "central vein sign" (CVS), a linear hypointensity on T2*-weighted imaging corresponding to a central vein/venule, is associated with multiple sclerosis (MS) lesions. The effect of lesion-size exclusion criteria on MS diagnostic accuracy has not been extensively studied. Objective: Investigate the optimal lesion-size exclusion criteria for CVS use in MS diagnosis. Methods: Cross-sectional study of 163 MS and 51 non-MS, and radiological/histopathological correlation of 5 MS and 1 control autopsy cases. The effects of lesion-size exclusion on MS diagnosis using the CVS, and intralesional vein detection on histopathology were evaluated. Results: CVS+ lesions were larger compared to CVS- lesions, with effect modification by MS diagnosis (mean difference +7.7 mm(3), p = 0.004). CVS percentage-based criteria with no lesion-size exclusion showed the highest diagnostic accuracy in differentiating MS cases. However, a simple count of three or more CVS+ lesions greater than 3.5 mm is highly accurate and can be rapidly implemented (sensitivity 93%; specificity 88%). On magnetic resonance imaging (MRI)-histopathological correlation, the CVS had high specificity for identifying intralesional veins (0/7 false positives). Conclusion: Lesion-size measures add important information when using CVS+ lesion counts for MS diagnosis. The CVS is a specific biomarker corresponding to intralesional veins on histopathology.

引用

页码：1891 / 1902

页数：12

共 33 条

[11] MRI criteria for the diagnosis of multiple sclerosis: MAGNIMS consensus guidelines [J].

Filippi, Massimo ;

Rocca, Maria A. ;

Ciccarelli, Olga ;

De Stefano, Nicola ;

Evangelou, Nikos ;

Kappos, Ludwig ;

Rovira, Alex ;

Sastre-Garriga, Jaume ;

Tintore, Mar ;

Frederiksen, Jette L. ;

Gasperini, Claudio ;

Palace, Jacqueline ;

Reich, Daniel S. ;

Banwell, Brenda ;

Montalban, Xavier ;

Barkhof, Frederik .

LANCET NEUROLOGY, 2016, 15 (03) :292-303

[12]

HOROWITZ AL, 1989, AM J NEURORADIOL, V10, P303

[13] Evaluation of 2016 MAGNIMS MRI criteria for dissemination in space in patients with a clinically isolated syndrome [J].

Hyun, Jae-Won ;

Huh, So-Young ;

Kim, Woojun ;

Park, Min Su ;

Ahn, Suk-Won ;

Cho, Joong-Yang ;

Kim, Byung-Jo ;

Lee, Sang-Hyun ;

Kim, Su-Hyun ;

Kim, Ho Jin .

MULTIPLE SCLEROSIS JOURNAL, 2018, 24 (06) :758-766

[14] Preventing multiple sclerosis misdiagnosis using the "central vein sign": A real-world study [J].

Kaisey, Marwa ;

Solomon, Andrew J. ;

Guerrero, Brooke L. ;

Renner, Brian ;

Fan, Zhaoyang ;

Ayala, Natalie ;

Luu, Michael ;

Diniz, Marcio A. ;

Sati, Pascal ;

Sicotte, Nancy L. .

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2021, 48

[15] Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers [J].

Kaisey, Marwa ;

Solomon, Andrew J. ;

Luu, Michael ;

Giesser, Barbara S. ;

Sicotte, Nancy L. .

MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2019, 30 :51-56

[16] Improved differentiation between MS and vascular brain lesions using FLAIR* at 7 Tesla [J].

Kilsdonk, Iris D. ;

Wattjes, Mike P. ;

Lopez-Soriano, Alexandra ;

Kuijer, Joost P. A. ;

de Jong, Marcus C. ;

de Graaf, Wolter L. ;

Conijn, Mandy M. A. ;

Polman, Chris H. ;

Luijten, Peter R. ;

Geurts, Jeroen J. G. ;

Geerlings, Mirjam I. ;

Barkhof, Frederik .

EUROPEAN RADIOLOGY, 2014, 24 (04) :841-849

[17] Defining the clinical course of multiple sclerosis: Results of an international survey [J].

Lublin, FD ;

Reingold, SC .

NEUROLOGY, 1996, 46 (04) :907-911

[18] CVSnet: A machine learning approach for automated central vein sign assessment in multiple sclerosis [J].

Maggi, Pietro ;

Fartaria, Mario Joao ;

Jorge, Joao ;

La Rosa, Francesco ;

Absinta, Martina ;

Sati, Pascal ;

Meuli, Reto ;

Du Pasquier, Renaud ;

Reich, Daniel S. ;

Cuadra, Meritxell Bach ;

Granziera, Cristina ;

Richiardi, Jonas ;

Kober, Tobias .

NMR IN BIOMEDICINE, 2020, 33 (05)

[19] Central vein sign differentiates Multiple Sclerosis from central nervous system inflammatory vasculopathies [J].

Maggi, Pietro ;

Absinta, Martina ;

Grammatico, Matteo ;

Vuolo, Luisa ;

Emmi, Giacomo ;

Carlucci, Giovanna ;

Spagni, Gregorio ;

Barilaro, Alessandro ;

Repice, Anna Maria ;

Emmi, Lorenzo ;

Prisco, Domenico ;

Martinelli, Vittorio ;

Scotti, Roberta ;

Sadeghi, Niloufar ;

Perrotta, Gaetano ;

Sati, Pascal ;

Dachy, Bernard ;

Reich, Daniel S. ;

Filippi, Massimo ;

Massacesi, Luca .

ANNALS OF NEUROLOGY, 2018, 83 (02) :283-294

[20] Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis [J].

McDonald, WI ;

Compston, A ;

Edan, G ;

Goodkin, D ;

Hartung, HP ;

Lublin, FD ;

McFarland, HF ;

Paty, DW ;

Polman, CH ;

Reingold, SC ;

Sandberg-Wollheim, M ;

Sibley, W ;

Thompson, AJ ;

van den Noort, S ;

Weinshenker, BY ;

Wolinsky, JS .

ANNALS OF NEUROLOGY, 2001, 50 (01) :121-127

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