Evaluation of Biocoat® intestinal epithelium differentiation environment (3-day cultured Caco-2 cells) as an absorption screening model with improved productivity

被引：87
作者：
Chong, SH [1 ]
Dando, SA [1 ]
Morrison, RA [1 ]
机构：
[1] Bristol Myers Squibb Pharmaceut Res Inst, Dept Metab & Pharmacokinet, Princeton, NJ 08543 USA
来源：
PHARMACEUTICAL RESEARCH | 1997年 / 14卷 / 12期
关键词：
Biocoat (R) intestinal epithelium differentiation environment; in vitro epithelial model; Caco-2; cells;
D O I：
10.1023/A:1012112820371
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：1835 / 1837
页数：3
相关论文
共 17 条
[1]   CORRELATION BETWEEN ORAL-DRUG ABSORPTION IN HUMANS AND APPARENT DRUG PERMEABILITY COEFFICIENTS IN HUMAN INTESTINAL EPITHELIAL (CACO-2) CELLS [J].
ARTURSSON, P ;
KARLSSON, J .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 175 (03) :880-885
[2]   PHARMACOKINETIC EVALUATION IN MAN OF TERBUTALINE GIVEN AS SEPARATE ENANTIOMERS AND AS THE RACEMATE [J].
BORGSTROM, L ;
NYBERG, L ;
JONSSON, S ;
LINDBERG, C ;
PAULSON, J .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 27 (01) :49-56
[3]   In vitro permeability through Caco-2 cells is not quantitatively predictive of in vivo absorption for peptide-like drugs absorbed via the dipeptide transporter system [J].
Chong, SH ;
Dando, SA ;
Soucek, KM ;
Morrison, RA .
PHARMACEUTICAL RESEARCH, 1996, 13 (01) :120-123
[4]   Comparison of HT29-18-C-1 and Caco-2 cell lines as models for studying intestinal paracellular drug absorption [J].
Collett, A ;
Sims, E ;
Walker, D ;
He, YL ;
Ayrton, J ;
Rowland, M ;
Warhurst, G .
PHARMACEUTICAL RESEARCH, 1996, 13 (02) :216-221
[5]  
COLLINS RF, 1976, BRIT J CLIN PHARMACO, V3, pP346
[6]  
DREYFUSS J, 1977, J CLIN PHARM MAY, P300
[7]  
Everett Donald W., 1992, Pharmaceutical Research (New York), V9, pS316
[8]   CLINICAL PHARMACOKINETICS OF PARACETAMOL [J].
FORREST, JAH ;
CLEMENTS, JA ;
PRESCOTT, LF .
CLINICAL PHARMACOKINETICS, 1982, 7 (02) :93-107
[9]   Pharmacokinetics of losartan, an angiotensin II receptor antagonist, and its active metabolite EXP3174 in humans [J].
Lo, MW ;
Goldberg, MR ;
McCrea, JB ;
Lu, H ;
Furtek, CI ;
Bjornsson, TD .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1995, 58 (06) :641-649
[10]  
MARKS V, 1973, LANCET, V1, P827
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