Limitations of antibiotic options for invasive infections caused by methicillin-resistant Staphylococcus aureus: is combination therapy the answer?

被引：94

作者：

Nguyen, Hien M. ^{[1
]}

Graber, Christopher J. ^{[1
,2
]}

机构：

[1] VA Greater Los Angeles Healthcare Syst, Infect Dis Sect, Los Angeles, CA 90073 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2010年 / 65卷 / 01期

关键词：

MRSA; combination treatment; bactericidal agents; community-acquired infections; BLOOD-STREAM INFECTIONS; VITRO PHARMACODYNAMIC MODEL; PANTON-VALENTINE LEUKOCIDIN; SKIN-STRUCTURE INFECTIONS; SIMULATED ENDOCARDIAL VEGETATIONS; VANCOMYCIN PLUS RIFAMPIN; FOREIGN-BODY INFECTION; SMALL-COLONY VARIANT; IN-VITRO; QUINUPRISTIN-DALFOPRISTIN;

D O I：

10.1093/jac/dkp377

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Invasive infections caused by methicillin-resistant Staphylococcus aureus (MRSA), particularly those involving persistent bacteraemia, necrotizing pneumonia, osteomyelitis and other deep-seated sites of infections, are associated with high mortality and are often difficult to treat. The response to treatment of severe MRSA infection with currently available antibiotics active against MRSA is often unsatisfactory, leading some physicians to resort to combination antibiotic therapy. Now, with the emergence of community-associated MRSA (CA-MRSA) clones that display enhanced virulence potentially related to up-regulated toxin production, the use of adjuvant protein synthesis-inhibiting antibiotics to reduce toxin production also has been advocated by some experts. In this review, we discuss the limitations of antibiotics currently available for the treatment of serious invasive MRSA infections and review the existing literature that examines the potential role of combination therapy in these infections.

引用

页码：24 / 36

页数：13

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