Anti-Inflammatory Activity of Constituents Isolated from Ulmus davidiana var. japonica

被引：14

作者：

Zheng, Ming Shan ^{[1
,2
]}

Yang, Ju Hye ^{[1
]}

Li, Ying ^{[1
]}

Li, Xian ^{[1
]}

Chang, Hyeun Wook ^{[1
]}

Son, Jong-Keun ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Gyongsan 712749, South Korea

[2] Yanbian Univ, Coll Pharm, Yanji 133000, Peoples R China

来源：

BIOMOLECULES & THERAPEUTICS | 2010年 / 18卷 / 03期

关键词：

Ulmus davidiana var. japonica; Bone marrow-derived mast cells; Cyclooxygenase-2; 5-Lipoxygenase; beta-hexosaminidase; Anti-inflammatory activity; PLANCH ULMACEAE; GLYCOSIDES; INHIBITION; LEAVES; 5-LIPOXYGENASE; LIGNAN; CYCLOOXYGENASES-2; LICOFELONE; FRACTION; COLLAGEN;

D O I：

10.4062/biomolther.2010.18.3.321

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twenty six compounds (1-26) were isolated from the root barks of Ulmus davidiana var. japonica. The anti-inflammatory activity of the isolated compounds were evaluated against the generation of inflammatory chemical mediators in bone marrow-derived mast cells. Among them, compounds 10, 11, 13, 15 and 19 inhibited not only cyclooxygenase-2 dependent prostaglandin D-2 generation but also 5-lipoxygenase dependent leukotrien C-4 generation in a concentration-dependent manner. In addition, compounds 11, 12, 13, 15 and 19 also inhibited beta-hexosaminidase release, a marker of mast cell degranulation reaction, from bone marrow-derived mast cell. These results suggest that the anti-inflammatory activity of U. davidiana might in part occur by both the inhibition of eicosanoid generations and the degranulation reaction of mast cells.

引用

页码：321 / 328

页数：8

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