Role of Tet2 in Regulating Adaptive and Innate Immunity

被引：18

作者：

Li, Jiaqi ^{[1
]}

Li, Lifang ^{[2
]}

Sun, Xiaoxiao ^{[1
]}

Deng, Tuo ^{[1
]}

Huang, Gan ^{[1
]}

Li, Xia ^{[1
]}

Xie, Zhiguo ^{[1
]}

Zhou, Zhiguang ^{[1
]}

机构：

[1] Cent South Univ, Natl Clin Res Ctr Metab Dis, Key Lab Diabet Immunol, Minist Educ,Dept Metab & Endocrinol,Second Xiangy, Changsha, Peoples R China

[2] Cent South Univ, Dept Ultrasound, Third Xiangya Hosp, Changsha, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2021年 / 9卷

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

ten-eleven translocation-2; DNA methylation; gene regulation and expression; immune cell differentiation; autoinflammatory and autoimmune diseases; INFLAMMATORY GENE-EXPRESSION; HELPER-CELL SPECIFICATION; DNA DEMETHYLATION; B-CELLS; 5-METHYLCYTOSINE OXIDATION; TERMINAL DIFFERENTIATION; FOXP3; STABILITY; MECHANISMS; 5-HYDROXYMETHYLCYTOSINE; HEMATOPOIESIS;

D O I：

10.3389/fcell.2021.665897

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Accumulated evidence indicates that epigenetic modifications play central roles in gene expression regulation and participate in developing many autoimmune and autoinflammatory diseases. Mechanistically, epigenetic modifications act as a bridge between environmental and cellular factors and susceptibility genes. DNA methylation is a critical epigenetic modification that is regulated by ten-eleven translocation (TET) enzymes. Accumulating evidence has revealed that TET family proteins function as gene regulators and antitumor drug targets mainly because of their ability to oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Recently, the effect of Tet2, an essential TET protein, on the development of autoimmune diseases has been explored. In this review, we summarize the current understanding of Tet2 in immune response regulation, clarify the mechanisms of Tet2 in B and T cell differentiation and function, and discuss the opposing effects of Tet2 on inflammatory gene expression in the immune system to provide new potential therapeutic targets for related diseases.

引用

页数：14

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