Changes in purines concentration in the cerebrospinal fluid of patients experiencing pain: A case-control study

被引：8

作者：

Schmidt, Andre P. ^{[1
,2
]}

Boehmer, Ana Elisa ^{[1
]}

Soares, Felix A. ^{[1
]}

Posso, Irimar P. ^{[3
]}

Machado, Sheila B. ^{[4
]}

Mendes, Fiorentino F. ^{[4
]}

Portela, Luis Valmor C. ^{[1
]}

Souza, Diogo O. ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Dept Biochem, ICBS, Porto Alegre, RS, Brazil

[2] HCPA, Dept Anesthesia & Perioperat Med, Porto Alegre, RS, Brazil

[3] Univ Sao Paulo, Fac Med, Hosp Clin, Disciplina Anestesiol, BR-05508 Sao Paulo, Brazil

[4] Univ Fed Ciencias Saude Porto Alegre, Fac Med, Dept Cirugia, Porto Alegre, RS, Brazil

来源：

NEUROSCIENCE LETTERS | 2010年 / 474卷 / 02期

关键词：

Purines; Guanosine; Inosine; Chronic pain; Cerebrospinal fluid; Somatic pain; GUANINE-BASED PURINES; NITRIC-OXIDE; AMINO-ACIDS; QUINOLINIC ACID; SPINAL-CORD; GUANOSINE; ADENOSINE; IMMUNE; WOMEN; CSF;

D O I：

10.1016/j.neulet.2010.02.067

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study analyzes the relationship between extracellular purines and pain perception in humans. Cerebrospinal fluid (CSF) levels of purines and their metabolites were compared between patients displaying acute and/or chronic pain syndromes and control subjects. The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05). Patients displaying both chronic and acute pain presented similar changes in the CSF purines concentration (P<0.05). However, in the acute pain group, only CSF inosine and uric acid levels were significantly increased (P<0.05). These findings suggest that purines, in special inosine, guanosine and uric acid, are associated with the spinal mechanisms underlying nociception. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：69 / 73

页数：5

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