Biotinylated Chlorin and Its Zinc and Indium Complexes: Synthesis and In Vitro Biological Evaluation for Photodynamic Therapy

被引：20

作者：

Isaac-Lam, Meden F. ^{[1
]}

Hammonds, Dewana M. ^{[1
]}

机构：

[1] Purdue Univ Northwest, Dept Chem & Phys, 1401 S US Hwy 421, Westville, IN 46391 USA

来源：

PHARMACEUTICALS | 2017年 / 10卷 / 02期

关键词：

photodynamic therapy; PDT; chlorin-biotin conjugate; zinc chlorin-biotin complex; indium chlorin-biotin complex; vitamin-targeted cancer therapeutics; DRUG-DELIVERY; CANCER; PORPHYRINS; PHOTOSENSITIZERS; RECEPTOR; MECHANISM; PRODRUG; CARRIER; TRENDS; AGENTS;

D O I：

10.3390/ph10020041

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and characterization of biotinylated chlorin photosensitizer and the corresponding zinc and indium complexes are described for potential applications in photodynamic therapy (PDT) for cancer. Phototoxicity of the biotin-chlorin conjugate and the metallated complexes was determined in colon carcinoma CT26 cell lines known to overexpress biotin (Vit B-7) receptors. Cell survival assay indicated that the biotinylated chlorin and indium complex showed increased cell growth inhibition than the zinc complex and the starting chlorin (methyl pheophorbide). Fluorescence microcopy studies revealed the generation of apoptotic cells upon light irradiation of colon cells treated with the indium complex. Targeting biotin receptors in cancer cells can improve specificity of photosensitizers for PDT applications.

引用

页数：12

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