A rare form of dermatomyositis associated with muscle weakness and normal creatine kinase level

被引:8
作者
Kwan, Christopher [1 ]
Milosevic, Suzana [1 ]
Benham, Helen [2 ]
Scott, Ian A. [1 ]
机构
[1] Princess Alexandra Hosp Hlth Serv Dist, Dept Gen Med, Brisbane, Qld, Australia
[2] Princess Alexandra Hosp Hlth Serv Dist, Dept Rheumatol, Brisbane, Qld, Australia
关键词
general practice; family medicine; rheumatology; dermatology; MODIFIER ACTIVATING ENZYME; ANTI-SAE ANTIBODIES; MYCOPHENOLATE-MOFETIL; GENE; 5; INTRAVENOUS IMMUNOGLOBULIN; CUTANEOUS DERMATOMYOSITIS; RIG-I; AUTOANTIBODIES; POLYMYOSITIS; PREVALENCE;
D O I
10.1136/bcr-2019-232260
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We present a case study of a 61-year-old Vietnamese woman who presents with features of dermatomyositis (DM), including Gottron's papules, heliotrope rash, cutaneous ulcers, generalised weakness and pain, and weight loss with normal levels of creatine kinase (CK). She demonstrated features of interstitial lung disease and subsequently tested positive for anti-melanoma differentiation-associated gene 5 and anti-small ubiquitin-like modifier 1 activating enzyme antibodies, which belong to a DM subtype known as clinically amyopathic dermatomyositis and do not present with raised CK. She received standard treatment for DM, including oral prednisolone, hydroxychloroquine, mycopheonlate and topical betamethasone. The treatment successfully reversed skin changes; however, the patient remained generally weak and unable to carry out her activities of daily living.
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页数:5
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