Age-dependent inverse correlations in CSF and plasma amyloid-β(1-42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice

被引：28

作者：

Cho, Soo Min ^{[1
,2
]}

Lee, Sejin ^{[1
,2
]}

Yang, Seung-Hoon ^{[1
]}

Kim, Hye Yun ^{[1
,2
,3
]}

Lee, Michael Jisoo ^{[1
,8
]}

Kim, Hyunjin Vincent ^{[1
,2
]}

Kim, Jiyoon ^{[1
,2
]}

Baek, Seungyeop ^{[1
,7
]}

Yun, Jin ^{[1
,2
]}

Kim, Dohee ^{[1
,7
]}

Kim, Yun Kyung ^{[1
,2
]}

Cho, Yakdol ^{[4
,5
]}

Woo, Jiwan ^{[4
,5
]}

Kim, Tae Song ^{[6
]}

Kim, YoungSoo ^{[1
,2
]}

机构：

[1] Ctr Neuromed, Hwarangno 14 Gil 5, Seoul, South Korea

[2] Korea Univ Sci & Technol, Biol Chem Program, 217 Gajungro, Daejeon, South Korea

[3] GoshenBiotech, 83-2 Wolmun Ri, Namyangju Si, Gyeonggi Do, South Korea

[4] Ctr Neurosci, Seoul, South Korea

[5] Hwarangno 14 Gil 5, Seoul, South Korea

[6] Korea Inst Sci & Technol, Brain Sci Inst, Ctr BioMicroSyst, Hwarangno 14 Gil 5, Seoul, South Korea

[7] Yonsei Univ, Dept Biotechnol, 50 Yonsei Ro, Seoul 120749, South Korea

[8] Calif Northstate Univ, Coll Med, Dept Med Educ, 9700 W Taron Dr, Elk Grove, CA USA

来源：

SCIENTIFIC REPORTS | 2016年 / 6卷

关键词：

MILD COGNITIVE IMPAIRMENT; A-BETA; ALZHEIMERS-DISEASE; DEMENTIA; RISK; MODEL; ASSOCIATION; BIOMARKERS; DEFICITS; DECLINE;

D O I：

10.1038/srep20185

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Amyloid-beta (A beta) plays a critical role as a biomarker in Alzheimer's disease (AD) diagnosis. In addition to its diagnostic potential in the brain, recent studies have suggested that changes of A beta level in the plasma can possibly indicate AD onset. In this study, we found that plasma A beta(1-42) concentration increases with age, while the concentration of A beta(1-42) in the cerebrospinal fluid (CSF) decreases in APP(swe), PS1(M146V) and Tau(P301L) transgenic (3xTg-AD) mice, if measurements were made before formation of ThS-positive plaques in the brain. Our data suggests that there is an inverse correlations between the plasma and CSF A beta(1-42) levels until plaques form in transgenic mice's brains and that the plasma A beta concentration possesses the diagnostic potential as a biomarker for diagnosis of early AD stages.

引用

页数：9

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