Intraoperative effect of low doses of ketamine or dexmedetomidine continuous rate infusions in healthy dogs receiving propofol total intravenous anaesthesia and epidural anaesthesia: A prospective, randomised clinical study

被引:3
作者
Bustamante, Rocio [1 ]
Canfran, Susana [2 ]
Gomez de Segura, Ignacio A. [2 ]
Aguado, Delia [2 ]
机构
[1] Vetsia Vet Hosp, Anaesthesiol Serv, Calle Galileo 3, Madrid 28914, Spain
[2] Univ Complutense Madrid, Vet Fac, Vet Teaching Hosp, Anaesthesiol Serv,Dept Anim Med & Surg, Avda Puerta de Hierro S-N, Madrid 28040, Spain
关键词
Canine anaesthesia; Constant rate infusion; Dexmedetomidine; Dog; Propofol; TIVA; MINIMUM ALVEOLAR CONCENTRATION; ORTHOPEDIC-SURGERY; POSTOPERATIVE ANALGESIA; ISOFLURANE; CARDIOPULMONARY; INDUCTION; PHARMACOKINETICS; BUPRENORPHINE; PREMEDICATION; MAINTENANCE;
D O I
10.1016/j.rvsc.2021.12.017
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
The present study aimed to determine the effect of either ketamine or dexmedetomidine constant rate infusion (CRI) on intraoperative propofol anaesthetic requirements during total intravenous anaesthesia (TIVA) in healthy dogs undergoing hindlimbs orthopaedic procedures receiving epidural anaesthesia. In this randomised, blinded clinical study, thirty-nine healthy client-owned dogs were premedicated intramuscularly (dexmedetomidine 4 mu g/kg and methadone 0.3 mg/kg). General anaesthesia was induced to effect with propofol administered as intravenous bolus, and maintained with propofol TIVA (18 mg/kg/h), adjusted to meet the suitable clinical anaesthetic depth (indicatively +/- 20%) based on clinical judgement. Lumbosacral epidural anaesthesia was per-formed using bupivacaine (1 mg/kg) and morphine preservative free (0.1 mg/kg). Dogs randomly received either saline (SP; loading dose 1 mL/kg, CRI 1 mL/kg/h), or ketamine (KP; loading dose 1.5 mg/kg, CRI 1.5 mg/kg/h), or dexmedetomidine (DP; loading dose 1 mu g/kg/, CRI 1 mu g/kg/h). Physiological variables were recorded intra-operatively at 5-min intervals using standard-of-care monitoring. Recovery quality and duration were recorded. Treatment groups were compared with parametric and non-parametric tests as appropriate, p < 0.05. Propofol rates and recovery scores were similar between groups. Overall mean and diastolic blood pressures were higher in group DP compared to group KP (12-14 mmHg, p = 0.016 and p = 0.015, respectively). More dogs required mechanical ventilation in group KP (12 dogs) than in either group SP or DP (7 dogs per group, p = 0.037). Ketamine or dexmedetomidine CRIs, at the studied rates, did not reduce propofol TIVA requirements in dogs undergoing orthopaedic surgery with epidural anaesthesia.
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页码:4 / 12
页数:9
相关论文
共 44 条
[11]   Agreement between direct, oscillometric and Doppler ultrasound blood pressures using three different cuff positions in anesthetized dogs [J].
Garofalo, Natache A. ;
Teixeira Neto, Francisco J. ;
Alvaides, Renata K. ;
de Oliveira, Flavia A. ;
Pignaton, Wangles ;
Pinheiro, Renato T. .
VETERINARY ANAESTHESIA AND ANALGESIA, 2012, 39 (04) :324-334
[12]   SOME VENTILATORY EFFECTS OF PROPOFOL AS SOLE ANESTHETIC AGENT [J].
GOODMAN, NW ;
BLACK, AMS ;
CARTER, JA .
BRITISH JOURNAL OF ANAESTHESIA, 1987, 59 (12) :1497-1503
[13]   Subcutaneous pre-anaesthetic medication with acepromazine-buprenorphine is effective as and less painful than the intramuscular route [J].
Gurney, M. ;
Cripps, P. ;
Mosing, M. .
JOURNAL OF SMALL ANIMAL PRACTICE, 2009, 50 (09) :474-477
[14]  
Haskins S., 2015, LUMB JONES VET ANEST, V5th, P297
[15]   HYPOXIC VENTILATORY DRIVE IN DOGS DURING THIOPENTAL, KETAMINE, OR PENTOBARBITAL ANESTHESIA [J].
HIRSHMAN, CA ;
MCCULLOUGH, RE ;
COHEN, PJ ;
WEIL, JV .
ANESTHESIOLOGY, 1975, 43 (06) :628-634
[16]   Total intravenous anesthesia in greyhounds: Pharmacokinetics of propofol and fentanyl - A preliminary study [J].
Hughes, JML ;
Nolan, AM .
VETERINARY SURGERY, 1999, 28 (06) :513-524
[17]   Comparison of premedication with buprenorphine or methadone with meloxicam for postoperative analgesia in dogs undergoing orthopaedic surgery [J].
Hunt, J. R. ;
Attenburrow, P. M. ;
Slingsby, L. S. ;
Murrell, J. C. .
JOURNAL OF SMALL ANIMAL PRACTICE, 2013, 54 (08) :418-424
[18]   Balanced anesthetic techniques in dogs and cats [J].
Ilkiw, JE .
CLINICAL TECHNIQUES IN SMALL ANIMAL PRACTICE, 1999, 14 (01) :27-37
[19]  
JACOBSON JD, 1994, AM J VET RES, V55, P543
[20]   Epidural analgesia in the dog and cat [J].
Jones, RS .
VETERINARY JOURNAL, 2001, 161 (02) :123-131