The role of IL-6 in TBI and PTSD, a potential therapeutic target?

被引：12

作者：

Monsour, Molly ^{[1
]}

Croci, Davide Marco ^{[2
]}

Agazzi, Siviero ^{[1
,2
]}

机构：

[1] Univ S Florida, Morsani Coll Med, 12901 Bruce B Downs Blvd, Tampa, FL 33612 USA

[2] Univ S Florida, Morsani Coll Med, Dept Neurosurg & Brain Repair, Tampa, FL USA

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 2022年 / 218卷

关键词：

Interleukin-6; Posttraumatic stress disorder; Traumatic brain injury; TRAUMATIC BRAIN-INJURY; POSTTRAUMATIC-STRESS-DISORDER; QUALITY-OF-LIFE; INFLAMMATORY RESPONSE; SIGNAL TRANSDUCER; OXIDATIVE STRESS; INTERFERON-GAMMA; EPITHELIAL-CELLS; TRANSGENIC MICE; GROWTH-FACTOR;

D O I：

10.1016/j.clineuro.2022.107280

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This literature review focuses on the role of IL-6 in TBI or PTSD-induced neuroinflammation. While TBI and PTSD are widely prevalent, these diagnoses are particularly common amongst veterans. Given the role of IL-6 in neuroprotection acutely, compared to detrimental chronically, targeting this cytokine at specific time points may be beneficial in modulating neuroinflammation. Current treatments for TBI or PTSD are variably affective. By reviewing the role of IL-6 in these two diagnoses, future studies can focus on therapeutics to treat neuroinflammation and ultimately reduce the devastating impacts of neuroinflammation on cognition in PTSD and TBI.

引用

页数：6

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