Global, Regional, and National Burden of Diabetes-Related Chronic Kidney Disease From 1990 to 2019

被引:200
作者
Deng, Yujiao [1 ,2 ]
Li, Na [2 ]
Wu, Ying [2 ]
Wang, Meng [2 ]
Yang, Si [2 ]
Zheng, Yi [2 ]
Deng, Xinyue [3 ]
Xiang, Dong [4 ]
Zhu, Yuyao [2 ]
Xu, Peng [2 ]
Zhai, Zhen [2 ]
Zhang, Dai [2 ]
Dai, Zhijun [3 ]
Gao, Jie [1 ]
机构
[1] Xi An Jiao Tong Univ, Dept Nephrol, Affiliated Hosp 2, Xian, Peoples R China
[2] Xi An Jiao Tong Univ, Dept Oncol, Affiliated Hosp 2, Xian, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Breast Surg, Hangzhou, Peoples R China
[4] Oregon Hlth Sci Ctr Affiliated Midcolumbia Med Ct, Celilo Canc Ctr, The Dallas, OR USA
关键词
diabetes-related chronic kidney disease; mortality; disability-adjusted life-years; incidence; prevalence; SYSTEMATIC ANALYSIS; MORTALITY; EPIDEMIOLOGY; ASSOCIATIONS; DISPARITIES; PREVALENCE; COUNTRIES; ANEMIA; TYPE-1;
D O I
10.3389/fendo.2021.672350
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus-related CKD (CKD-DM) could provide specific support to lessen global, regional, and national CKD burden. Methods Data were derived from the GBD 2019 study, including four measures and age-standardized rates (ASRs). Estimated annual percentage changes and 95% CIs were calculated to evaluate the variation trend of ASRs. Results Diabetes caused the majority of new cases and patients with CKD in all regions. All ASRs for type 2 diabetes-related CKD increased over 30 years. Asia and Middle socio-demographic index (SDI) quintile always carried the heaviest burden of CKD-DM. Diabetes type 2 became the second leading cause of CKD and CKD-related death and the third leading cause of CKD-related DALYs in 2019. Type 2 diabetes-related CKD accounted for most of the CKD-DM disease burden. There were 2.62 million incident cases, 134.58 million patients, 405.99 thousand deaths, and 13.09 million disability-adjusted life-years (DALYs) of CKD-DM worldwide in 2019. Age-standardized incidence (ASIR) and prevalence rate (ASPR) of type 1 diabetes-related CKD increased, whereas age-standardized death rate (ASDR) and DALY rate decreased for females and increased for males. In high SDI quintile, ASIR and ASPR of type 1 diabetes-related CKD remained the highest, with the slowest increase, whereas the ASDR and age-standardized DALY rate remained the lowest there. In high SDI quintile, ASIR of type 2 diabetes-related CKD was the highest, with the lowest increasing rate. In addition, type 2 diabetes-related CKD occurred most in people aged 80-plus years worldwide. The main age of type 2 diabetes-related CKD patients was 55-64 years in Asia and Africa. The prevalence, mortality, and DALY rate of type 2 diabetes-related CKD increased with age. As for incidence, there was a peak at 80 years, and after age of 80, the incidence declined. CKD-DM-related anemia was mainly in mild to moderate grade. Conclusions Increasing burden of CKD-DM varied among regions and countries. Prevention and treatment measures should be strengthened according to CKD-DM epidemiology, especially in middle SDI quintile and Asia.
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页数:15
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