A spectroscopic and molecular modeling of sinomenine binding to transferrin

被引：22
作者：
Du, Hongyan
Xiang, Junfeng
Zhang, Yazhou
Tang, Yalin [1 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci,BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100080, Peoples R China
[2] Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 06期
关键词：
sinomenine; transferrin; binding; transport;
D O I：
10.1016/j.bmcl.2006.12.069
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Sinomenine, an herbal ingredient isolated from Sinomenium acutum, is used for the amelioration of arthritis. It has been found that this molecule could bind to human serum transferrin (Tf), the iron (III) transport protein in the blood, by using fluorescence, circular dichroism (CD) spectroscopy, and molecular modeling methods. The results provide possible usage of transferrin to transport sinomenine. (c) 2006 Elsevier Ltd. All rights reserved.
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收藏
页码：1701 / 1704
页数：4
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