DIFFERENTIAL PULSE VOLTAMMETRIC DETERMINATION OF SILDENAFIL CITRATE (VIAGRA®) IN PHARMACEUTICAL FORMULATIONS USING A BORON-DOPED DIAMOND ELECTRODE

被引：53

作者：

Batista, Erica Ferreira ^{[1
]}

Sartori, Elen Romao ^{[1
]}

Medeiros, Roberta Antigo ^{[1
]}

Rocha-Filho, Romeu C. ^{[1
]}

Fatibello-Filho, Orlando ^{[1
]}

机构：

[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP, Brazil

来源：

ANALYTICAL LETTERS | 2010年 / 43卷 / 06期

基金：

巴西圣保罗研究基金会;

关键词：

Boron-doped diamond electrode; Differential pulse voltammetry; Pharmaceutical formulations; Sildenafil citrate (Viagra (R)) determination; SQUARE-WAVE; SPECTROPHOTOMETRIC DETERMINATION; ELECTROCHEMICAL-BEHAVIOR; COUNTERFEIT VIAGRA(R); MEMBRANE SENSORS; PRODUCTS; SPECTROSCOPY; ASPARTAME; CYCLAMATE; ASSAY;

D O I：

10.1080/00032710903491153

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The determination of sildenafil citrate using differential pulse voltammetry and a cathodically pre-treated boron-doped diamond electrode is described. The obtained analytical curve is linear in the sildenafil concentration range 7.3 x 10(-7) - 7.3 x 10(-6) mol L-1 in a 0.1 mol L-1 H2SO4, with a detection limit of 6.4 x 10(-7) mol L-1. The proposed method, which is fast and simple to carry out, was successfully applied in the determination of sildenafil citrate in Viagra (R) pharmaceutical formulations, with results in close agreement (at 95% confidence level) with those obtained using a comparative HPLC method.

引用

页码：1046 / 1054

页数：9

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