Interchangeable parts of the Escherichia coli recombination machinery

被引：76

作者：

Amundsen, SK ^{[1
]}

Smith, GR ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

CELL | 2003年 / 112卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(03)00197-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Escherichia coli, at least two groups of proteins, or "recombination machines," can operate independently on broken DNA to produce a X-terminated single-stranded DNA filament coated with RecA protein and ready for synapsis with intact homologous DNA. Recent analyses of mutants lacking one or more of the activities required for presynaptic filament formation by one recombination machine demonstrate that parts of the two normally separate machines can interchange to initiate homologous recombination.

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收藏

页码：741 / 744

页数：4

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