The human glutamate receptor δ2 gene (GRID2) maps to chromosome 4q22

被引：22

作者：

Hu, W ^{[1
]}

Zuo, J ^{[1
]}

De Jager, PL ^{[1
]}

Heintz, N ^{[1
]}

机构：

[1] Rockefeller Univ, Howard Hughes Med Inst, New York, NY 10021 USA

来源：

GENOMICS | 1998年 / 47卷 / 01期

关键词：

D O I：

10.1006/geno.1997.5108

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We isolated the human glutamate receptor delta 2 (GRID2) gene, which has 97.0% identity in amino acid sequence to the mouse glutamate receptor delta 2 (Grid2) gene. We subsequently mapped this gene to human chromosome 4q22 by radiation hybrid mapping and by hybridization to two overlapping human yeast artificial chromosomes that are located in 4q22. The Grid2 gene, which is mutated in lurcher (Lc) mice, maps to mouse chromosome 6. Thus, the mapping of the GRID2 gene to human chromosome 4q22 confirms and refines a region of synteny between mouse and human genomes. (C) 1998 Academic Press.

引用

页码：143 / 145

页数：3

共 11 条

[1] Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis [J].

BenArie, N ;

McCall, AE ;

Berkman, S ;

Eichele, G ;

Bellen, HJ ;

Zoghbi, HY .

HUMAN MOLECULAR GENETICS, 1996, 5 (09) :1207-1216

[2] STRUCTURAL AND QUANTITATIVE STUDIES ON THE NORMAL C3H AND LURCHER MUTANT MOUSE [J].

CADDY, KWT ;

BISCOE, TJ .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1979, 287 (1020) :167-&

[3]

CHOI DW, 1995, TRENDS NEUROSCI, V18, P58

[4] A new allele of the lurcher gene, lurcher(J) [J].

DeJager, PL ;

Zuo, J ;

Cook, SA ;

Heintz, N .

MAMMALIAN GENOME, 1997, 8 (09) :647-650

[5] An similar to 1.2-Mb bacterial artificial chromosome contig refines the genetic and physical maps of the lurcher locus on mouse chromosome 6 [J].

DeJager, PL ;

Zuo, JA ;

Heintz, N .

GENOME RESEARCH, 1997, 7 (07) :736-746

[6] CLONED GLUTAMATE RECEPTORS [J].

HOLLMANN, M ;

HEINEMANN, S .

ANNUAL REVIEW OF NEUROSCIENCE, 1994, 17 :31-108

[7]

PHILLIPS RITA J. S., 1960, JOUR GENET, V57, P35, DOI 10.1007/BF02985337

[8] An STS-based radiation hybrid map of the human genome [J].

Stewart, EA ;

McKusick, KB ;

Aggarwal, A ;

Bajorek, E ;

Brady, S ;

Chu, A ;

Fang, N ;

Hadley, D ;

Harris, M ;

Hussain, S ;

Lee, R ;

Maratukulam, A ;

OConnor, K ;

Perkins, S ;

Piercy, M ;

Qin, F ;

Reif, T ;

Sanders, C ;

She, XH ;

Sun, WL ;

Tabar, P ;

Voyticky, S ;

Cowles, S ;

Fan, JB ;

Mader, C ;

Quackenbush, J ;

Myers, RM ;

Cox, DR .

GENOME RESEARCH, 1997, 7 (05) :422-433

[9]

WETTS R, 1982, J EMBRYOL EXP MORPH, V68, P87

[10] Neurodegeneration in Lurcher mice caused by mutation in delta 2 glutamate receptor gene [J].

Zuo, J ;

DeJager, PL ;

Takahashi, KA ;

Jiang, WN ;

Linden, DJ ;

Heintz, N .

NATURE, 1997, 388 (6644) :769-773

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