Model of SOS-induced mutagenesis in bacteria Escherichia coli under ultraviolet irradiation

被引：11

作者：

Belov, Oleg V. ^{[1
]}

Krasavin, Evgeny A. ^{[1
]}

Parkhomenko, Alexander Yu. ^{[1
]}

机构：

[1] Joint Inst Nucl Res, Radiat Biol Lab, Dubna 141980, Moscow Region, Russia

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2009年 / 261卷 / 03期

关键词：

SOS response; DNA repair; UV mutagenesis; Mathematical modeling; DNA-POLYMERASE-II; ERROR-PRONE; TRANSLESION SYNTHESIS; PROTEIN; REPAIR; SIGNAL; UMUD; PURIFICATION; SYSTEM; ROLES;

D O I：

10.1016/j.jtbi.2009.08.016

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A mathematical model of the mutation process in bacteria Escherichia coli induced by ultraviolet radiation is developed. Our model is based on the experimental data characterizing the main processes of the bacterial SOS response. Here we have modeled a whole sequence of the events leading to the fixation of the primary DNA lesion as a point mutation. A quantitative analysis of the key ways of the SOS mutagenesis was performed in terms of modern system biology. The dynamic changes of the basic SOS protein concentrations and the process of the translesion synthesis by the modified replication complex are described quantitatively. We have also demonstrated the applicability of the developed model to the description of the mutagenesis in individual genes. As an example, an estimation of the mutation frequency in E. coli's lacI gene is performed. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：388 / 395

页数：8

共 46 条

[1] DISSOCIATION OF RECA FILAMENTS FROM DUPLEX DNA BY THE RUVA AND RUVB DNA-REPAIR PROTEINS [J].

ADAMS, DE ;

TSANEVA, IR ;

WEST, SC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (21) :9901-9905

[2] Dynamics of the inducing signal for the SOS regulatory system in Escherichia coli after ultraviolet irradiation [J].

Aksenov, SV .

MATHEMATICAL BIOSCIENCES, 1999, 157 (1-2) :269-286

[3]

[Anonymous], MUTAGENIC ACTION RAD

[4] Time Dependence of the Inducing Signal of the E. coli SOS System under Ultraviolet Irradiation [J].

Belo, O. V. .

PHYSICS OF PARTICLES AND NUCLEI LETTERS, 2007, 4 (06) :519-523

[5]

BELOV OV, 2006, B DUBNA INT U NAT SO, V2, P39

[6]

BIANCO PR, 1999, ENCY LIFE SCI

[7] DNA POLYMERASE-II IS ENCODED BY THE DNA DAMAGE-INDUCIBLE DINA GENE OF ESCHERICHIA-COLI [J].

BONNER, CA ;

HAYS, S ;

MCENTEE, K ;

GOODMAN, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7663-7667

[8] Escherichia coli DNA polymerase III can replicate efficiently past a T-T cis-syn cyclobutane dimer if DNA polymerase v and the 3′ to 5′ exonuclease proofreading function encoded by dnaQ are inactivated [J].

Borden, A ;

O'Grady, PI ;

Vandewiele, D ;

de Henestrosa, ARF ;

Lawrence, CW ;

Woodgate, R .

JOURNAL OF BACTERIOLOGY, 2002, 184 (10) :2674-2681

[9] UMUD MUTAGENESIS PROTEIN OF ESCHERICHIA-COLI - OVERPRODUCTION, PURIFICATION, AND CLEAVAGE BY RECA [J].

BURCKHARDT, SE ;

WOODGATE, R ;

SCHEUERMANN, RH ;

ECHOLS, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (06) :1811-1815

[10]

Cadet J., 1990, BIOORGANIC PHOTOCHEM, V1, P1

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