Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

被引：77

作者：

Cederbaum, Arthur I. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 11期

关键词：

Cytochrome P450 2E1; S-adenosyl-L-methionine; Ethanol; Toxic hepatitis; Oxidative stress; ISOLATED RAT HEPATOCYTES; FOLATE-DEFICIENT DIET; MICROPIGS FED ETHANOL; HIGH-FAT DIET; OXIDATIVE STRESS; ADENOSYLMETHIONINE SYNTHETASE; NONALCOHOLIC STEATOHEPATITIS; LIPID-PEROXIDATION; DIFFERENTIAL EXPRESSION; FUNCTIONAL-CHARACTERIZATION;

D O I：

10.3748/wjg.v16.i11.1366

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection. (C) 2010 Baishideng. All rights reserved.

引用

页码：1366 / 1376

页数：11

共 102 条

[21] Introduction - Serial review: Alcohol, oxidative stress and cell injury [J].

Cederbaum, AI .

FREE RADICAL BIOLOGY AND MEDICINE, 2001, 31 (12) :1524-1526

[22] S-adenosylmethionine deficiency and TNF-α in lipopolysaccharide-induced hepatic injury [J].

Chawla, RK ;

Watson, WH ;

Eastin, CE ;

Lee, EY ;

Schmidt, J ;

McClain, CJ .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1998, 275 (01) :G125-G129

[23]

Colell A, 1997, HEPATOLOGY, V26, P699, DOI 10.1053/jhep.1997.v26.pm0009303501

[24] INHIBITION OF GLUTATHIONE SYNTHESIS IN THE LIVER LEADS TO S-ADENOSYL-L-METHIONINE SYNTHETASE REDUCTION [J].

CORRALES, F ;

OCHOA, P ;

RIVAS, C ;

MARTINLOMAS, M ;

MATO, JM ;

PAJARES, MA .

HEPATOLOGY, 1991, 14 (03) :528-533

[25] In vivo regulation by glutathione of methionine adenosyltransferase S-nitrosylation in rat liver [J].

Corrales, FJ ;

Ruiz, F ;

Mato, JM .

JOURNAL OF HEPATOLOGY, 1999, 31 (05) :887-894

[26] S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism [J].

del Pilar Cabrales-Romero, Maria ;

Marquez-Rosado, Lucrecia ;

Fattel-Fazenda, Samia ;

Trejo-Solis, Cristina ;

Arce-Popoca, Evelia ;

Aleman-Lazarini, Leticia ;

Villa-Trevino, Saul .

WORLD JOURNAL OF GASTROENTEROLOGY, 2006, 12 (12) :1895-1904

[27] S-adenosyl methionine protects ob/ob mice from CYP2E1-mediated liver injury [J].

Dey, Aparajita ;

Caro, Andres A. ;

Cederbaum, Arthur I. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2007, 293 (01) :G91-G103

[28] Induction of cytochrome promotes liver injury in ob/ob mice [J].

Dey, Aparajita ;

Cederbaum, Arthur I. .

HEPATOLOGY, 2007, 45 (06) :1355-1365

[29] RAT-LIVER MICROSOMAL NADPH-SUPPORTED OXIDASE ACTIVITY AND LIPID-PEROXIDATION DEPENDENT ON ETHANOL-INDUCIBLE CYTOCHROME-P-450 (P-450IIE1) [J].

EKSTROM, G ;

INGELMANSUNDBERG, M .

BIOCHEMICAL PHARMACOLOGY, 1989, 38 (08) :1313-1319

[30] Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs [J].

Esfandiari, F ;

Villanueva, JA ;

Wong, DH ;

French, SW ;

Halsted, CH .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 289 (01) :G54-G63

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