Hepatoprotective effects of S-adenosyl-L-methionine against alcohol- and cytochrome P450 2E1-induced liver injury

被引：77
作者：
Cederbaum, Arthur I. [1 ]
机构：
[1] Mt Sinai Sch Med, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 11期
关键词：
Cytochrome P450 2E1; S-adenosyl-L-methionine; Ethanol; Toxic hepatitis; Oxidative stress; ISOLATED RAT HEPATOCYTES; FOLATE-DEFICIENT DIET; MICROPIGS FED ETHANOL; HIGH-FAT DIET; OXIDATIVE STRESS; ADENOSYLMETHIONINE SYNTHETASE; NONALCOHOLIC STEATOHEPATITIS; LIPID-PEROXIDATION; DIFFERENTIAL EXPRESSION; FUNCTIONAL-CHARACTERIZATION;
D O I：
10.3748/wjg.v16.i11.1366
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
S-adenosyl-L-methionine (SAM) acts as a methyl donor for methylation reactions and participates in the synthesis of glutathione. SAM is also a key metabolite that regulates hepatocyte growth, differentiation and death. Hepatic SAM levels are decreased in animal models of alcohol liver injury and in patients with alcohol liver disease or viral cirrhosis. This review describes the protection by SAM against alcohol and cytochrome P450 2E1-dependent cytotoxicity both in vitro and in vivo and evaluates mechanisms for this protection. (C) 2010 Baishideng. All rights reserved.
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页码：1366 / 1376
页数：11
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