The use of statins in intensive care unit patients with sepsis

被引:3
作者
Bromilow, J. [1 ]
Bruce, M. J. L. Schuster [1 ]
机构
[1] Royal Perth Hosp, Intens Care Unit, Dept Anaesthesia, Perth, WA 6001, Australia
关键词
sepsis; intensive care unit; statin; critical illness;
D O I
10.1177/0310057X0703500215
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
The incidence of sepsis is increasing and remains the leading cause of death in critically ill patients. The statin group of drugs appear to have important anti-inflammatory effects and may have a role in the treatment of sepsis. However, current prescribing guidelines recommend that statin therapy is discontinued in critically ill patients. We found no evidence to support commencing statin therapy in patients with sepsis on an intensive care unit and low levels of evidence to support continuing established therapy in this patient population.
引用
收藏
页码:256 / 258
页数:3
相关论文
共 13 条
[1]   Current epidemiology of septic shock - The CUB-Rea network [J].
Annane, D ;
Aegerter, P ;
Jars-Guincestre, MC ;
Guidet, B .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2003, 168 (02) :165-172
[2]  
[Anonymous], 2006, PRESCRIBING INFORM
[3]   Efficacy and safety of recombinant human activated protein C for severe sepsis. [J].
Bernard, GR ;
Vincent, JL ;
Laterre, P ;
LaRosa, SP ;
Dhainaut, JF ;
Lopez-Rodriguez, A ;
Steingrub, JS ;
Garber, GE ;
Helterbrand, JD ;
Ely, EW ;
Fisher, CJ .
NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) :699-709
[4]  
Diehl JL, 2005, CURR OPIN CRIT CARE, V11, P454
[5]  
Dunzendorfer S, 1997, CIRC RES, V81, P963
[6]   Superoxide anion overproduction in sepsis: effects of vitamin E and simvastatin [J].
Durant, R ;
Klouche, K ;
Delbosc, S ;
Morena, M ;
Amigues, L ;
Beraud, JJ ;
Canaud, B ;
Cristol, JP .
SHOCK, 2004, 22 (01) :34-39
[7]   Benefit versus risk in statin treatment [J].
Guyton, JR .
AMERICAN JOURNAL OF CARDIOLOGY, 2006, 97 (8A) :95C-97C
[8]   Statin therapy is associated with fewer deaths in patients with bacteraemia [J].
Kruger, P ;
Fitzsimmons, K ;
Cook, D ;
Jones, M ;
Nimmo, G .
INTENSIVE CARE MEDICINE, 2006, 32 (01) :75-79
[9]   The effect of statins on mortality in patients with bacteremia [J].
Liappis, AP ;
Kan, VL ;
Rochester, CG ;
Simon, GL .
CLINICAL INFECTIOUS DISEASES, 2001, 33 (08) :1352-1357
[10]   HMG-CoA reductase inhibitor simvastatin profoundly improves survival in a murine model of sepsis [J].
Merx, MW ;
Liehn, EA ;
Janssens, U ;
Lütticken, R ;
Schrader, J ;
Hanrath, P ;
Weber, C .
CIRCULATION, 2004, 109 (21) :2560-2565