Novel synthesis of β-lactams and their biological evaluation

Stereoselective synthesis of racemic and optically active novel beta-lactams using Staudinger cycloaddition reaction with imines and ketenes has been achieved. Microwave induced-reactions have been performed for the preparation of these types of beta-lactams and products derived from them. The formation of trans-beta-lactams has been rationalized via isomerization of the enolates formed between the reactions of acid chloride (equivalent) with imines in the presence of a tertiary base. A donor-acceptor complex formation has been found to be the intermediate occurred in the formation of cis-beta-lactams. A peri hydrogen in the aromatic rings has been proved to be crucial in controlling the isomer distribution of the products. Glycosylation reaction has been performed to prepare a few intermdeaites that are useful for anticancer agents. Cell-growth inhibition study has identified a few beta-lactams that demonstrates anticancer activity. Microwave-induced reactions have been conducted for the synthesis of diverse heterocycles using beta-lactams as the starting compounds.