Differential roles of leptin in regulating cell migration in thyroid cancer cells

被引:42
作者
Cheng, Shih-Ping [3 ,4 ]
Yin, Pen-Hui [1 ]
Chang, Yuan-Ching [4 ]
Lee, Chen-Hsen [1 ,2 ,5 ]
Huang, Shih-Yuan [4 ]
Chi, Chin-Wen [1 ,3 ]
机构
[1] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
[2] Taipei Vet Gen Hosp, Dept Surg, Taipei 11217, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei 112, Taiwan
[4] Mackay Mem Hosp, Dept Surg, Taipei, Taiwan
[5] Natl Yang Ming Univ, Sch Med, Dept Surg, Taipei 112, Taiwan
关键词
leptin; leptin receptor; thyroid cancer; migration; adipokines; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; MESSENGER-RNA; IODIDE UPTAKE; CYCLIN D1; IN-VITRO; EXPRESSION; RECEPTOR; INVASION; MECHANISMS;
D O I
10.3892/or_00000817
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Excess body weight is associated with a moderately increased risk of thyroid cancer. Adipocyte-derived hormone, leptin, has been shown to enhance cell growth and migration in many cancer types. Limited evidence suggests that leptin has direct actions on the thyroid gland, but there are no data available on the effect of leptin on thyroid cancer cells. We evaluated the action of leptin on gene expression, cell growth, cell cycle, and cell migration in anaplastic (ARO), follicular (WRO) and papillary (CGTH-W3) thyroid carcinoma cell lines. Expression of long-form leptin receptors was observed in all thyroid cancer cell lines. Leptin stimulation did not alter the expression levels of leptin, leptin receptor and sodium-iodide symporter. Cell growth and cell cycle were not changed after leptin treatment. However, leptin was able to promote cell migration of papillary thyroid cancer cells, but inhibited migration of anaplastic and follicular cancer cells. In summary, our study suggests that leptin modulates cell migration of thyroid cancer cells in a cell type-specific manner.
引用
收藏
页码:1721 / 1727
页数:7
相关论文
共 30 条
  • [1] Obesity and cancer
    Calle, EE
    Thun, MJ
    [J]. ONCOGENE, 2004, 23 (38) : 6365 - 6378
  • [2] Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway
    Chen, Chiachen
    Chang, Yuan-Ching
    Liu, Chien-Liang
    Liu, Tsang-Pai
    Chang, King-Jen
    Guo, Ing-Cherng
    [J]. ENDOCRINE-RELATED CANCER, 2007, 14 (02) : 513 - 529
  • [3] Leptin-induced growth of human ZR-75-1 breast cancer cells is associated with up-regulation of cyclin D1 and c-Myc and down-regulation of tumor suppressor p53 and p21WAF1/CIP1
    Chen, Chiachen
    Chang, Yuan-Ching
    Liu, Chien-Liang
    Chang, King-Jen
    Guo, Ing-Cherng
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2006, 98 (02) : 121 - 132
  • [4] Characteristics of well-differentiated thyroid cancer associated with multinodular goiter
    Cheng, Shih-Ping
    Liu, Chien-Liang
    Tzen, Chi-Yuan
    Yang, Tsen-Long
    Jeng, Kuo-Shyang
    Liu, Tsang-Pai
    Lee, Jie-Jen
    [J]. LANGENBECKS ARCHIVES OF SURGERY, 2008, 393 (05) : 729 - 732
  • [5] Risk factors for thyroid cancer: an epidemiological review focused on nutritional factors
    Dal Maso, Luigino
    Bosetti, Cristina
    La Vecchia, Carlo
    Franceschi, Silvia
    [J]. CANCER CAUSES & CONTROL, 2009, 20 (01) : 75 - 86
  • [6] Increasing incidence of thyroid cancer in the United States, 1973-2002
    Davies, L
    Welch, HG
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (18): : 2164 - 2167
  • [7] Acute and chronic leptin effect upon in vivo and in vitro rat thyroid iodide uptake
    De Oliveira, Elaine
    Fagundes, Aline Teixeira Silva
    Bonomo, Isabela Teixeira
    Flavio, Henrique Curty
    Passos, Magna Cottini Fonseca
    de Moura, Egberto Gaspar
    Lisboa, Patricia Cristina
    [J]. LIFE SCIENCES, 2007, 81 (15) : 1241 - 1246
  • [8] Body size and thyroid cancer in two million Norwegian men and women
    Engeland, A.
    Tretli, S.
    Akslen, L. A.
    Bjorge, T.
    [J]. BRITISH JOURNAL OF CANCER, 2006, 95 (03) : 366 - 370
  • [9] Polarity proteins in migration and invasion
    Etienne-Manneville, S.
    [J]. ONCOGENE, 2008, 27 (55) : 6970 - 6980
  • [10] Thyroid and leptin
    Feldt-Rasmussen, Ulla
    [J]. THYROID, 2007, 17 (05) : 413 - 419