Differential roles of leptin in regulating cell migration in thyroid cancer cells
被引:42
作者:
Cheng, Shih-Ping
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Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei 112, Taiwan
Mackay Mem Hosp, Dept Surg, Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Cheng, Shih-Ping
[3
,4
]
Yin, Pen-Hui
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Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, TaiwanTaipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Yin, Pen-Hui
[1
]
Chang, Yuan-Ching
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Mackay Mem Hosp, Dept Surg, Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Chang, Yuan-Ching
[4
]
Lee, Chen-Hsen
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机构:
Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Taipei Vet Gen Hosp, Dept Surg, Taipei 11217, Taiwan
Natl Yang Ming Univ, Sch Med, Dept Surg, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Lee, Chen-Hsen
[1
,2
,5
]
Huang, Shih-Yuan
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Mackay Mem Hosp, Dept Surg, Taipei, TaiwanTaipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Huang, Shih-Yuan
[4
]
Chi, Chin-Wen
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机构:
Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei 112, TaiwanTaipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
Chi, Chin-Wen
[1
,3
]
机构:
[1] Taipei Vet Gen Hosp, Dept Med Res & Educ, Taipei 11217, Taiwan
[2] Taipei Vet Gen Hosp, Dept Surg, Taipei 11217, Taiwan
[3] Natl Yang Ming Univ, Sch Med, Dept & Inst Pharmacol, Taipei 112, Taiwan
[4] Mackay Mem Hosp, Dept Surg, Taipei, Taiwan
[5] Natl Yang Ming Univ, Sch Med, Dept Surg, Taipei 112, Taiwan
Excess body weight is associated with a moderately increased risk of thyroid cancer. Adipocyte-derived hormone, leptin, has been shown to enhance cell growth and migration in many cancer types. Limited evidence suggests that leptin has direct actions on the thyroid gland, but there are no data available on the effect of leptin on thyroid cancer cells. We evaluated the action of leptin on gene expression, cell growth, cell cycle, and cell migration in anaplastic (ARO), follicular (WRO) and papillary (CGTH-W3) thyroid carcinoma cell lines. Expression of long-form leptin receptors was observed in all thyroid cancer cell lines. Leptin stimulation did not alter the expression levels of leptin, leptin receptor and sodium-iodide symporter. Cell growth and cell cycle were not changed after leptin treatment. However, leptin was able to promote cell migration of papillary thyroid cancer cells, but inhibited migration of anaplastic and follicular cancer cells. In summary, our study suggests that leptin modulates cell migration of thyroid cancer cells in a cell type-specific manner.
机构:
Ist Ric Farmacol Mario Negri, Milan, ItalyCtr Riferimento Oncol, Unita Epidemiol & Biostat, I-33081 Aviano, PN, Italy
Bosetti, Cristina
La Vecchia, Carlo
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机构:
Ist Ric Farmacol Mario Negri, Milan, Italy
Univ Milan, Ist Stat Med & Biometria GA Maccacaro, Milan, ItalyCtr Riferimento Oncol, Unita Epidemiol & Biostat, I-33081 Aviano, PN, Italy
La Vecchia, Carlo
Franceschi, Silvia
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Int Agcy Res Canc, F-69372 Lyon, FranceCtr Riferimento Oncol, Unita Epidemiol & Biostat, I-33081 Aviano, PN, Italy
机构:
Inst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France
CNRS, URA 2582, F-74724 Paris 15, FranceInst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France
机构:
Ist Ric Farmacol Mario Negri, Milan, ItalyCtr Riferimento Oncol, Unita Epidemiol & Biostat, I-33081 Aviano, PN, Italy
Bosetti, Cristina
La Vecchia, Carlo
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机构:
Ist Ric Farmacol Mario Negri, Milan, Italy
Univ Milan, Ist Stat Med & Biometria GA Maccacaro, Milan, ItalyCtr Riferimento Oncol, Unita Epidemiol & Biostat, I-33081 Aviano, PN, Italy
La Vecchia, Carlo
Franceschi, Silvia
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h-index: 0
机构:
Int Agcy Res Canc, F-69372 Lyon, FranceCtr Riferimento Oncol, Unita Epidemiol & Biostat, I-33081 Aviano, PN, Italy
机构:
Inst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France
CNRS, URA 2582, F-74724 Paris 15, FranceInst Pasteur, Cell Polar & Migrat Grp, F-74724 Paris 15, France