Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk

被引：52

作者：

Bethke, Lara ^{[1
]}

Webb, Emily ^{[1
]}

Sellick, Gabrielle ^{[1
]}

Rudd, Matthew ^{[1
]}

Penegar, Stephen ^{[1
]}

Withey, Laura ^{[1
]}

Qureshi, Mobshra ^{[1
]}

Houlston, Richard ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Surrey, England

来源：

BMC CANCER | 2007年 / 7卷 / 1期

关键词：

D O I：

10.1186/1471-2407-7-123

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Cytochrome P450 (CYP) enzymes have the potential to affect colorectal cancer (CRC) risk by determining the genotoxic impact of exogenous carcinogens and levels of sex hormones. Methods: To investigate if common variants of CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1 and CYP19A1 influence CRC risk we genotyped 2,575 CRC cases and 2,707 controls for 20 single nucleotide polymorphisms ( SNPs) that have not previously been shown to have functional consequence within these genes. Results: There was a suggestion of increased risk, albeit insignificant after correction for multiple testing, of CRC for individuals homozygous for CYP1B1 rs162558 and heterozygous for CYP1A2 rs2069522 ( odds ratio [ OR] = 1.36, 95% confidence interval [CI]: 1.03-1.80 and OR = 1.34, 95% CI: 1.00-1.79 respectively). Conclusion: This study provides some support for polymorphic variation in CYP1A2 and CYP1B1 playing a role in CRC susceptibility.

引用

页数：7

共 27 条

[1]

ADAMS B, 2002, CAHIERS CARIBEENS EG, V3, P5

[2] Cytochrome P450 gene polymorphism and cancer [J].

Agúndez, JAG .

CURRENT DRUG METABOLISM, 2004, 5 (03) :211-224

[3] Mapping complex disease loci in whole-genome association studies [J].

Carlson, CS ;

Eberle, MA ;

Kruglyak, L ;

Nickerson, DA .

NATURE, 2004, 429 (6990) :446-452

[4] Meat-related mutagens/carcinogens in the etiology of colorectal cancer [J].

Cross, AJ ;

Sinha, R .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2004, 44 (01) :44-55

[5] Human extrahepatic cytochromes P450: Function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts [J].

Ding, XX ;

Kaminsky, LS .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2003, 43 :149-173

[6] Polymorphisms associated with circulating sex hormone levels in postmenopausal women [J].

Dunning, AM ;

Dowsett, M ;

Healey, CS ;

Tee, L ;

Luben, RN ;

Folkerd, E ;

Novik, KL ;

Kelemen, L ;

Ogata, S ;

Pharoah, PDP ;

Easton, DF ;

Day, NE ;

Ponder, BAJ .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (12) :936-945

[7]

Gibson P, 2003, MOL CANCER THER, V2, P527

[8]

Giovannucci E, 2001, CANCER EPIDEM BIOMAR, V10, P725

[9] RELATIONSHIP OF DIET TO RISK OF COLORECTAL ADENOMA IN MEN [J].

GIOVANNUCCI, E ;

STAMPFER, MJ ;

COLDITZ, G ;

RIMM, EB ;

WILLETT, WC .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (02) :91-98

[10]

GIOVANNUCCI E, 1994, CANCER RES, V54, P2390

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