Inactivation of S-adenosyl-L-homocysteine hydrolase with novel 5′-thioadenosine derivatives.: Antiviral effects

被引：7

作者：

Guillerm, G

Guillerm, D

Vandenplas-Vitkowski, C

Glapski, C

De Clercq, E

机构：

[1] UFR Sci, Chim Bioorgan Lab, UMR 6519, F-51687 Reims 2, France

[2] Katholieke Univ Leuven, Rega Inst Med Res, Louvain, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 10期

关键词：

D O I：

10.1016/S0960-894X(03)00279-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of 5'-S-vinyl-5'-thioadenosine 5, 5'-S-ethynyl-5'-thioadenosine 7 and 5'-S-cyano-5'-thioadenosine 9 is described. Incubation of AdoHcy hydrolase with 5, 7 and 9 resulted in time- and concentration-dependent inactivation of the enzyme and partial depletion of its NAD(+) content. From these results and characterisation of metabolites released during the inactivation process, hypothetical mechanisms are suggested. The antiviral activity of 5, 7 and 9 was examined. Significant activities were noted with 5 against Vaccinia, Junin and Taccaribe viruses. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：1649 / 1652

页数：4