A Contemporary Treatment Approach to Both Diabetes and Depression by Cordyceps sinensis, Rich in Vanadium

被引:40
作者
Guo, Jian-You [2 ]
Han, Chun-Chao [3 ]
Liu, Yong-Mei [1 ]
机构
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Mol Biol Lab, Beijing 100053, Peoples R China
[2] Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Sch Pharm, Jinan 250355, Peoples R China
基金
中国国家自然科学基金;
关键词
antidepressants; vanadium enriched Cordyceps sinensis; diabetes; depression; high blood sugar-diabetes; HYPOGLYCEMIC ACTIVITY; COPRINUS-COMATUS; MUSHROOM; VANADATE; GLUCOSE; ADULTS; RATS;
D O I
10.1093/ecam/nep201
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Diabetes mellitus is accompanied by hormonal and neurochemical changes that can be associated with anxiety and depression. Both diabetes and depression negatively interact, in that depression leads to poor metabolic control and hyperglycemia exacerbates depression. We hypothesize one novel vanadium complex of vanadium-enriched Cordyceps sinensis (VECS), which is beneficial in preventing depression in diabetes, and influences the long-term course of glycemic control. Vanadium compounds have the ability to imitate the action of insulin, and this mimicry may have further favorable effects on the level of treatment satisfaction and mood. C. sinensis has an antidepressant-like activity, and attenuates the diabetes-induced increase in blood glucose concentrations. We suggest that the VECS may be a potential strategy for contemporary treatment of depression and diabetes through the co-effect of C. sinensis and vanadium. The validity of the hypothesis can most simply be tested by examining blood glucose levels, and swimming and climbing behavior in streptozotocin-induced hyperglycemic rats.
引用
收藏
页码:387 / 389
页数:3
相关论文
共 33 条