Antimicrobial Resistance Investigation on Staphylococcus Strains in a Local Hospital in Guangzhou, China, 2001-2010

被引：69

作者：

Deng, Yang ^{[1
]}

Liu, Junyan ^{[1
]}

Peters, Brian M. ^{[2
]}

Chen, Lei ^{[3
]}

Miao, Jian ^{[1
]}

Li, Bing ^{[1
]}

Li, Lin ^{[1
]}

Chen, Dingqiang ^{[4
]}

Yu, Guangchao ^{[5
]}

Xu, Zhenbo ^{[1
,6
]}

Shirtliff, Mark E. ^{[6
,7
]}

机构：

[1] S China Univ Technol, Coll Light Ind & Food Sci, Guangzhou 510640, Guangdong, Peoples R China

[2] Louisiana State Univ, Sch Dent, Hlth Sci Ctr, Dept Oral Biol, New Orleans, LA 70119 USA

[3] Anhui Acad Agr Sci, Inst Agroprod Proc, Hefei, Peoples R China

[4] Guangzhou Med Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou, Guangdong, Peoples R China

[5] Jinan Univ, Affiliated Hosp 1, Clin Lab Ctr, Guangzhou, Guangdong, Peoples R China

[6] Univ Maryland, Sch Dent, Dept Microbial Pathogenesis, Baltimore, MD 21201 USA

[7] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

来源：

MICROBIAL DRUG RESISTANCE | 2015年 / 21卷 / 01期

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

ANTIBIOTIC-RESISTANCE; SOUTH CHINA; AUREUS; INTEGRON;

D O I：

10.1089/mdr.2014.0117

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A retrospective study was conducted on 1,739 Staphylococcus isolates from the First Affiliated Hospital of Jinan University (FAHJU) in Guangzhou during 2001-2010. With the exception of teicoplanin and vancomycin, antimicrobial resistance was commonly observed among the isolates examined, with high resistance rates for beta-lactamases (94.0% and 73.7% for penicillin and oxacillin) and resistance percentages for cefoxitin, chloramphenicol, ciprofloxacin, clindamycin, erythromycin, gentamicin, trimethoprim-sulfamethoxazole, and tetracycline ranging from 83.9% to 19.4%. Two hundred sixty-three of the 1,739 isolates were subjected to SCCmec typing and 42 to MLST, spaA, and coa typing. ST239-MRSA-III was prevalently identified along with one distinct coa type HIJKL and 2 spaA types (WGKAOMQ-t037 and WGKAQQ-t030). Class 1 integrons were commonly detected (31.6%), although none of the integron-positive MRSA strains had been isolated since 2009. The widespread detection of integron-based antimicrobial resistance determinants may further contribute to the emergence of superbugs.

引用

页码：102 / 104

页数：3

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