Perceptions of epigenetics

被引:1914
作者
Bird, Adrian [1 ]
机构
[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh EH9 3JR, Midlothian, Scotland
基金
英国惠康基金;
关键词
D O I
10.1038/nature05913
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Geneticists study the gene; however, for epigeneticists, there is no obvious `epigene'. Nevertheless, during the past year, more than 2,500 articles, numerous scientific meetings and a new journal were devoted to the subject of epigenetics. It encompasses some of the most exciting contemporary biology and is portrayed by the popular press as a revolutionary new science - an antidote to the idea that we are hard-wired by our genes. So what is epigenetics?
引用
收藏
页码:396 / 398
页数:3
相关论文
共 18 条
[1]   Epigenetic transgenerational actions of endocrine disruptors and mate fertility [J].
Anway, MD ;
Cupp, AS ;
Uzumcu, M ;
Skinner, MK .
SCIENCE, 2005, 308 (5727) :1466-1469
[2]   The Drosophila Fab-7 chromosomal element conveys epigenetic inheritance during mitosis and meiosis [J].
Cavalli, G ;
Paro, R .
CELL, 1998, 93 (04) :505-518
[3]   Epigenetic germline inheritance [J].
Chong, SY ;
Whitelaw, E .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (06) :692-696
[4]   An epigenetic mutation responsible for natural variation in floral symmetry [J].
Cubas, P ;
Vincent, C ;
Coen, E .
NATURE, 1999, 401 (6749) :157-161
[5]   DNA methylation profiling of human chromosomes 6, 20 and 22 [J].
Eckhardt, Florian ;
Lewin, Joern ;
Cortese, Rene ;
Rakyan, Vardhman K. ;
Attwood, John ;
Burger, Matthias ;
Burton, John ;
Cox, Tony V. ;
Davies, Rob ;
Down, Thomas A. ;
Haefliger, Carolina ;
Horton, Roger ;
Howe, Kevin ;
Jackson, David K. ;
Kunde, Jan ;
Koenig, Christoph ;
Liddle, Jennifer ;
Niblett, David ;
Otto, Thomas ;
Pettett, Roger ;
Seemann, Stefanie ;
Thompson, Christian ;
West, Tony ;
Rogers, Jane ;
Olek, Alex ;
Berlin, Kurt ;
Beck, Stephan .
NATURE GENETICS, 2006, 38 (12) :1378-1385
[6]   Epigenetic differences arise during the lifetime of monozygotic twins [J].
Fraga, MF ;
Ballestar, E ;
Paz, MF ;
Ropero, S ;
Setien, F ;
Ballestart, ML ;
Heine-Suñer, D ;
Cigudosa, JC ;
Urioste, M ;
Benitez, J ;
Boix-Chornet, M ;
Sanchez-Aguilera, A ;
Ling, C ;
Carlsson, E ;
Poulsen, P ;
Vaag, A ;
Stephan, Z ;
Spector, TD ;
Wu, YZ ;
Plass, C ;
Esteller, M .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10604-10609
[7]   Transcriptional control of cognitive development [J].
Hong, EJ ;
West, AE ;
Greenberg, ME .
CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (01) :21-28
[8]   AZACYTIDINE-INDUCED REACTIVATION OF A DNA-REPAIR GENE IN CHINESE-HAMSTER OVARY CELLS [J].
JEGGO, PA ;
HOLLIDAY, R .
MOLECULAR AND CELLULAR BIOLOGY, 1986, 6 (08) :2944-2949
[9]   Genomic DNA methylation: the mark and its mediators [J].
Klose, RJ ;
Bird, AP .
TRENDS IN BIOCHEMICAL SCIENCES, 2006, 31 (02) :89-97
[10]   DNA replication fidelity [J].
Kunkel, TA .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (17) :16895-16898