Normalization of diabetic wound healing

被引：21
作者：
Francis-Goforth, Kellie N. [2 ]
Harken, Alden H. [2 ]
Saba, Julie D. [1 ]
机构：
[1] Childrens Hosp, Oakland Res Inst, Canc Biol Lab, Oakland, CA 94609 USA
[2] Univ Calif San Francisco E Bay, Dept Gen Surg, San Francisco, CA USA
来源：
SURGERY | 2010年 / 147卷 / 03期
基金：
美国国家卫生研究院;
关键词：
SPHINGOSINE; 1-PHOSPHATE; SPHINGOSINE-1-PHOSPHATE; GROWTH; ANGIOGENESIS; FIBROBLAST; RECEPTOR;
D O I：
10.1016/j.surg.2009.04.038
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Hypothesis: Impaired wound healing in diabetics is due to pathologic angiogenesis, which is a result of aberrant sphingosine-1-phosphate signaling. Pharmacologic modulation of sphingosine-1-phosphate-dependent signaling normalizes healing in diabetic wounds. © 2010 Mosby, Inc. All rights reserved.
引用
收藏
页码：446 / 449
页数：4
相关论文
共 12 条
  • [1] Increase of laminin 5 synthesis in human keratinocytes by acute wound fluid, inflammatory cytokines and growth factors, and lysophospholipids
    Amano, S
    Akutsu, N
    Ogura, Y
    Nishiyama, T
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2004, 151 (05) : 961 - 970
  • [2] Sphingosine 1-phosphate accelerates wound healing in diabetic mice
    Kawanabe, Takeshi
    Kawakami, Tamihiro
    Yatomi, Yutaka
    Shimada, Shinji
    Soma, Yoshinao
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2007, 48 (01) : 53 - 60
  • [3] Cellular dysfunction in the diabetic fibroblast - Impairment in migration, vascular endothelial growth factor production, and response to hypoxia
    Lerman, OZ
    Galiano, RD
    Armour, M
    Levine, JP
    Gurtner, GC
    [J]. AMERICAN JOURNAL OF PATHOLOGY, 2003, 162 (01) : 303 - 312
  • [4] Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation
    Liu, YJ
    Wada, R
    Yamashita, T
    Mi, YD
    Deng, CX
    Hobson, JP
    Rosenfeldt, HM
    Nava, VE
    Chae, SS
    Lee, MJ
    Liu, CH
    Hla, T
    Spiegel, S
    Proia, RL
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (08) : 951 - 961
  • [5] Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network
    Rosen, H
    Goetzl, EJ
    [J]. NATURE REVIEWS IMMUNOLOGY, 2005, 5 (07) : 560 - 570
  • [6] Point-counterpoint of sphingosine 1-phosphate metabolism
    Saba, JD
    Hla, T
    [J]. CIRCULATION RESEARCH, 2004, 94 (06) : 724 - 734
  • [7] The sphingosine 1-phosphate receptor S1P2 triggers hepatic wound healing
    Serriere-Lanneau, Valerie
    Teixeira-Clerc, Fatima
    Li, Liying
    Schippers, Marlies
    de Wries, Willie
    Julien, Boris
    Tran-Van-Nhieu, Jeanne
    Manin, Sylvie
    Poelstra, Klaas
    Chun, Jerold
    Carpentier, Stephane
    Levade, Thierry
    Mallat, Ariane
    Lotersztajn, Sophie
    [J]. FASEB JOURNAL, 2007, 21 (09) : 2005 - 2013
  • [8] Essential role of sphingosine 1-phosphate receptor 2 in pathological angiogenesis of the mouse retina
    Skoura, Athanasia
    Sanchez, Teresa
    Claffey, Kevin
    Mandala, Suzanne M.
    Proia, Richard L.
    Hla, Timothy
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) : 2506 - 2516
  • [9] Inside-Out signaling of sphingosine-1-phosphate: Therapeutic targets
    Takabe, Kazuaki
    Paugh, Steven W.
    Milstien, Sheldon
    Spiegel, Sarah
    [J]. PHARMACOLOGICAL REVIEWS, 2008, 60 (02) : 181 - 195
  • [10] Impaired wound healing in an acute diabetic pig model and the effects of local hyperglycemia
    Velander, Patrik
    Theopold, Christoph
    Hirsch, Tobias
    Bleiziffer, Oliver
    Zuhaili, Baraa
    Fossum, Magdalena
    Hoeller, Daniela
    Gheerardyn, Raphael
    Chen, Michael
    Visovatti, Scott
    Svensson, Henry
    Yao, Feng
    Eriksson, Elof
    [J]. WOUND REPAIR AND REGENERATION, 2008, 16 (02) : 288 - 293
12