In Vitro/in Vivo Evaluation of NCDS-Micro-fabricated Biodegradable Implant

被引：9

作者：

Park, Chun-Woong ^{[1
]}

Rhee, Yun-Seok ^{[1
]}

Park, Sung-Hoon ^{[1
]}

Danh, Son Dao ^{[1
]}

Ahn, Sung-Hoon ^{[2
,3
]}

Chi, Sang-Cheol ^{[1
]}

Park, Eun-Seok ^{[1
]}

机构：

[1] Sungkyunkwan Univ, Sch Mech, Suwon 440746, South Korea

[2] Seoul Natl Univ, Sch Mech & Aerosp Engn, Seoul 151742, South Korea

[3] Seoul Natl Univ, Inst Adv Machinery & Design, Seoul 151742, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2010年 / 33卷 / 03期

关键词：

5-Fluorouracil; PLGA; Hydroxyapatite; Microfabrication; Scaffold; DRUG-DELIVERY SYSTEM; RELEASE; MICROSPHERES;

D O I：

10.1007/s12272-010-0312-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Using the nano-composite deposition system (NODS) as a microfabrication technique, implantable scaffolds were prepared with poly(DL-lactide-co-glycolide)(85:15) [PLGA(85:15)] as a biodegradable polymer. 5-Fluorouracil (5-FU) was used as a model drug, and hydroxyapatite (HA) was incorporated as a release modifier. In vitro drug release was evaluated and we confirmed that HA could control the release of drug from the prepared scaffolds, especially in the initial phase of the release. Furthermore, in vivo tests demonstrated that the microfabricated scaffold with pores was useful in reducing immune response and maintained its original shape, indicating that the drug delivery system was highly biocompatible.

引用

页码：427 / 432

页数：6

共 12 条

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