An Eco-friendly Synthesis and Biological Screening of Fused Heterocyclic Compounds Containing a Thiophene Moiety via Gewald Reaction

被引：17
|
作者：
El-Borai, Mohamed A. [1 ]
Rizk, Hala F. [1 ]
Ibrahim, Seham A. [1 ]
Fares, Amira K. [1 ]
机构：
[1] Tanta Univ, Dept Chem, Fac Sci, Tanta 31527, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2019年 / 56卷 / 10期
关键词：
MICROWAVE-ASSISTED SYNTHESIS; CH-ACIDEN NITRILEN; 2-AMINOTHIOPHENE DERIVATIVES; ANTITUMOR; INHIBITORS; EFFICIENT; FACILE; ANTIOXIDANT; COMPLEXES; DESIGN;
D O I：
10.1002/jhet.3658
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
5-Amino-3-phenyl-1-(2,4,6-trichlorophenyl)-1H-thieno[3,2-c]pyrazole-6-carbonitrile (2) was designed and synthesized by one-pot multicomponent reaction. Compound 2 was reacted with different reagents to obtain new condensed moieties with our thienopyrazole skeleton. The compounds were prepared by using environmentally benign techniques as microwave irradiation, ultrasonic irradiation, and ball-milling. The structure of the prepared compounds was elucidated through spectroscopic methods. The new compounds were evaluated for their in vitro antibacterial and antifungal potentialities.
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页码：2787 / 2795
页数：9
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