Targeting early infection to prevent HIV-1 mucosal transmission

被引：470

作者：

Haase, Ashley T. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Microbiol, Minneapolis, MN 55455 USA

来源：

NATURE | 2010年 / 464卷 / 7286期

基金：

美国国家卫生研究院;

关键词：

SIMIAN IMMUNODEFICIENCY VIRUS; T-CELL DEPLETION; RHESUS MACAQUES; GENITAL-TRACT; INTRAVAGINAL INOCULATION; VAGINAL TRANSMISSION; MALE CIRCUMCISION; EPITHELIAL-CELLS; LYMPHOID-TISSUE; CERVICOVAGINAL MUCOSA;

D O I：

10.1038/nature08757

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.

引用

页码：217 / 223

页数：7

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