Optimizing the chitosan-PCL based membranes with random/aligned fiber structure for controlled ciprofloxacin delivery and wound healing

被引：55

作者：

Cui, Congjing ^{[1
]}

Sun, Shibin ^{[1
]}

Li, Xueyan ^{[1
]}

Chen, Shaojuan ^{[1
]}

Wu, Shaohua ^{[1
]}

Zhou, Fang ^{[1
]}

Ma, Jianwei ^{[1
]}

机构：

[1] Qingdao Univ, Coll Text & Clothing, Qingdao 266071, Shandong, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2022年 / 205卷

关键词：

Chitosan; Electrospun membranes; Ciprofloxacin; Antibacterial activity; Wound healing; COMPOSITE NANOFIBERS; IN-VIVO; ELECTROSPUN; PROLIFERATION; SCAFFOLDS; INFECTION; ADHESION; TISSUE;

D O I：

10.1016/j.ijbiomac.2022.02.118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of this study was to optimize the chitosan/polycaprolactone (CS/PCL) electrospun nanofibrous membrane with random/aligned fiber structures to provide a controlled release of ciprofloxacin (Cip) and guide skin fibroblasts arrangement. A series of Cip-encapsulated CS/PCL electrospun membranes were prepared by coaxialelectrospinning. The existence of Cip in core-shell structured fibers was confirmed by using SEM, TEM and FTIR characterizations. The in vitro drug-release profiles suggested that the Cip presented a sustained release for 15 days. Simultaneously, cyto-compatibility of the membranes decreased with the increasing amount of Cip from 2.0% to 5.0%. In particular, aligned CS/PCL membrane loading with 2.0% Cip exhibited a good balanced ability between cell proliferation and antibacterial effect (>99% against Escherichia coli and Staphylococcus aureus), which significantly accelerated the wound healing process in vivo. These results suggested that the aligned CS/ PCL membrane loading with 2.0% Cip exhibited great antibacterial property and biocompatibility, which possess promising applications potential for wound healing.

引用

页码：500 / 510

页数：11

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