Epidemiology of Non-Tuberculous Mycobacteria isolated from clinical specimens in Madrid, Spain, from 2013 to 2017

被引：17

作者：

Lopez-Roa, P. ^{[1
]}

Aznar, E. ^{[2
]}

Cacho, J. ^{[3
]}

Cogollos-Agruna, R. ^{[4
]}

Domingo, D. ^{[5
]}

Garcia-Arata, M., I ^{[6
]}

Millan, R. ^{[7
]}

Paez, M. ^{[8
]}

Perez-Cecilia, E. ^{[9
]}

Ruiz-Serrano, M. J. ^{[10
]}

Simon, M. ^{[11
]}

Tato, M. ^{[12
]}

Toro, C. ^{[13
]}

Valverde, J. F. ^{[14
]}

Esteban, J. ^{[15
]}

机构：

[1] Hosp 12 Octubre, Dept Microbiol, Madrid, Spain

[2] Lab Cent Madrid BRSalud, Madrid, Spain

[3] Hosp Univ Getafe, Dept Microbiol, Getafe, Spain

[4] Hosp Univ Mostoles, Dept Microbiol, Mostoles, Spain

[5] Hosp Univ La Princesa, Dept Microbiol, Madrid, Spain

[6] Hosp Univ Fuenlabrada, Dept Microbiol, Fuenlabrada, Spain

[7] Hosp Univ Puerta de Hierro, Dept Microbiol, Majadahonda, Spain

[8] Hosp Univ Severo Ochoa, Dept Microbiol, Leganes, Spain

[9] Hosp Clin San Carlos, Dept Microbiol, Madrid, Spain

[10] Hosp Gen Univ Gregorio Maranon, Dept Microbiol, Madrid, Spain

[11] Hosp Cent La Def Gomez Ulla, Dept Microbiol, Madrid, Spain

[12] Hosp Univ Ramon y Cajal, Dept Microbiol, Madrid, Spain

[13] Hosp Univ La Paz Carlos III Cantoblanco, Dept Microbiol, Madrid, Spain

[14] Fdn Hosp Alcorcon, Dept Microbiol, Alcorcon, Spain

[15] IIS Fdn Jimenez Diaz, Dept Clin Microbiol, Madrid, Spain

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2020年 / 39卷 / 06期

关键词：

Non-tuberculous mycobacteria; Epidemiology; Isolation rates; Mycobacterium lentiflavum; Mycobacterium abscessus; Mycobacterium; CYSTIC-FIBROSIS; INFECTIONS; ABSCESSUS;

D O I：

10.1007/s10096-020-03826-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The epidemiology of non-tuberculous mycobacteria (NTM) in Spain is largely unknown because systematic reporting is not compulsory. The aim of our study was to describe the frequency and diversity of NTM species in our region and their distribution according to the source sample, gender, and age of the patients. We performed a multicenter study of all NTM isolated in 24 public hospitals in Madrid from 2013 to 2017. A total of 6.923 mycobacteria were isolated: 4535 (65.5%) NTM, and 2.388 (34.5%) Mycobacterium tuberculosis complex (MTB). Overall, 61 different NTM species were identified. The most frequently isolated species were Mycobacterium avium complex (47.7%), M. lentiflavum (12.2%), M. gordonae (9.2%), M. fortuitum (8.9%), and M. abscessus (3.9%). Whereas MTB cases were stable during the study period, the number of NTM isolates increased considerably from 930 isolates in 2013 to 1012 in 2017; a sharp increase occurred in the last year. The rise in NTM isolates was mostly due to M. lentiflavum, M. kansasii, and M. abscessus mainly isolated from respiratory specimens in patients older than 60. The increase in isolation rate of NTM in our region is consistent with the increasing rates reported worldwide in the last decades. The rise in NTM isolates was mainly attributed to M. lentiflavum but it also should be noted the increasing of species with high pathogenic potential such as M. kansasii and M. abscessus.

引用

页码：1089 / 1094

页数：6

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