Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods

被引:1
作者
Shi, Zhen [1 ,2 ]
Wang, Yazhen [1 ,2 ,3 ]
Dong, Shaobo [2 ]
Lan, Tianyu [2 ]
机构
[1] Qiqihar Univ, Coll Mat Sci & Engn, Qiqihar 161006, Heilongjiang, Peoples R China
[2] Heilongjiang Prov Key Lab Polymer Composite Mat, Qiqihar 161006, Peoples R China
[3] Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin 150040, Heilongjiang, Peoples R China
关键词
NANOPARTICLES; DELIVERY;
D O I
10.1039/d1ra04256d
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe3O4-PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe3O4-PVA@SH prepared using both methods exhibited excellent drug delivery properties in an environment that simulates human body fluid (pH 7.2) and a lysosomal in vitro simulation (pH 4.7). In applications such as drug delivery, magnetic targeted drug carriers prepared by both methods demonstrated superparamagnetism, high fat solubility, high hydroxyl content, and good water solubility.
引用
收藏
页码:20670 / 20678
页数:9
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