Nickel-Catalyzed Stereoselective Dicarbofunctionalization of Alkynes

被引：103

作者：

Li, Zhaodong ^{[1
]}

Garcia-Dominguez, Andres ^{[1
]}

Nevado, Cristina ^{[1
]}

机构：

[1] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 24期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

alkyl halides; alkynes; boron; nickel; radicals; TETRASUBSTITUTED ALKENES; TERMINAL ALKYNES; GRIGNARD-REAGENTS; RADICAL REACTIONS; ARYL HALIDES; IODIDES; IRON; ELECTROPHILES; CARBOZINCATION; 1,2-ADDITION;

D O I：

10.1002/anie.201601296

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Anickel-catalyzed three-component reaction involving terminal alkynes, boronic acids, and alkyl halides is presented herein. Trisubstituted alkenes can be obtained in a highly regio- and stereocontrolled manner by the simultaneous addition of both aryl and alkyl groups across the triple bond in a radical-mediated process. The reaction, devoid of air- and moisture-sensitive organometallic reagents and catalysts, is operationally simple and offers a broad scope and functional-group tolerance.

引用

页码：6938 / 6941

页数：4

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