Nickel-Catalyzed Stereoselective Dicarbofunctionalization of Alkynes

被引：103
|
作者：
Li, Zhaodong [1 ]
Garcia-Dominguez, Andres [1 ]
Nevado, Cristina [1 ]
机构：
[1] Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 24期
基金：
欧洲研究理事会; 瑞士国家科学基金会;
关键词：
alkyl halides; alkynes; boron; nickel; radicals; TETRASUBSTITUTED ALKENES; TERMINAL ALKYNES; GRIGNARD-REAGENTS; RADICAL REACTIONS; ARYL HALIDES; IODIDES; IRON; ELECTROPHILES; CARBOZINCATION; 1,2-ADDITION;
D O I：
10.1002/anie.201601296
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Anickel-catalyzed three-component reaction involving terminal alkynes, boronic acids, and alkyl halides is presented herein. Trisubstituted alkenes can be obtained in a highly regio- and stereocontrolled manner by the simultaneous addition of both aryl and alkyl groups across the triple bond in a radical-mediated process. The reaction, devoid of air- and moisture-sensitive organometallic reagents and catalysts, is operationally simple and offers a broad scope and functional-group tolerance.
引用
收藏
页码：6938 / 6941
页数：4
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