Flame propagation through non-uniformly premixed gases occurs in several common combustion situations. Compared with the more usual limiting cases of diffusion or uniformly premixed flames, the practical concern of non-uniform premixed gas flame spread has received scant attention, especially regarding the potential role of gravity. This research examines a system in which a fuel concentration gradient exists normal to the direction of flame propagation and parallel with the gravitational vector. This paper presents experimental and numerical results for flame spread through alcohol/air layers formed by diffusive evaporation of liquid fuel at temperatures between the flash-point temperature and the stoichiometric temperature. A gallery, which had either the top and/or one end open to maintain constant pressure, surrounded the test section. The numerical simulations and experiments conducted include normal and microgravity cases. An interferometer was used, in normal gravity only, to determine the initial fuel layer thickness and fuel concentration distribution before and during flame spread. Both the model and experimental results show that the absence of gravity results in a faster spreading flame, by as much as 80% depending on conditions. This is the opposite effect to that predicted by an independent model reported earlier in this symposium series. Determination of the flame height showed that the flame was taller in microgravity, an effect also seen in the results of the numerical model reported here. Having a gallery lid results in faster flame spread, an effect more pronounced at normal gravity, demonstrating the importance of enclosure geometry. The interferometry and numerical model both indicated a redistribution of fuel vapor ahead of the flame. Numerical simulations show that, despite the rapid flame spread in these systems, the presence of gravity strongly affects the overall flow field in the gallery.