Microparticle Matrix Encoding of Beads

被引：16
作者：
Meldal, Morten [1 ]
Christensen, Soren Flygering [2 ]
机构：
[1] SPOCC Ctr, Carlsberg Lab, DK-2500 Valby, Denmark
[2] FeF Chem AS, DK-4600 Koge, Denmark
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 20期
基金：
新加坡国家研究基金会;
关键词：
automated screening; combinatorial chemistry; encoding; fluorescent tags; peptides; BINDING AFFINITIES; CHEMICAL LIBRARIES; COMBINATORIAL;
D O I：
10.1002/anie.200906563
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Reloaded matrix: Facile optical encoding of polyethylene glycol (PEC) based resins provides a direct identification of compounds in combinatorial libraries, and the structures may be correlated with bioactivity. The new technique, microparticle matrix (MPM) encoding (see picture), circumvents some problems often encountered in solid-phase combinatorial chemistry and is extremely simple to implement. (Figure Presented). © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：3473 / 3476
页数：4
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