Comprehensive in vitro studies of novel sol gel-derived Zr4+/Zn2+co-substituted bioactive glass with enhanced biological properties for bone healing

被引：18
作者：
Moghanian, Amirhossein [1 ]
Zohourfazeli, Mohammadamin [1 ]
Tajer, Mahzad Haji Mahdi [1 ]
Miri, Amir K. [2 ,3 ]
机构：
[1] Imam Khomeini Int Univ, Dept Mat Engn, Qazvin 3414916818, Iran
[2] Rowan Univ, Biofabricat Lab, Dept Mech Engn, Glassboro, NJ 08028 USA
[3] Rowan Univ, Sch Med Engn Sci & Hlth, Camden, NJ 08103 USA
来源：
JOURNAL OF NON-CRYSTALLINE SOLIDS | 2021年 / 566卷
关键词：
Sol-gel processes; Bioactive glass; ZrO2; Zinc; Bone healing; ANTIBACTERIAL ACTIVITY; DRUG-DELIVERY; CALCIUM-PHOSPHATE; ZINC; ZN; HYDROXYAPATITE; SCAFFOLDS; STRONTIUM; ZIRCONIA; PROLIFERATION;
D O I：
10.1016/j.jnoncrysol.2021.120887
中图分类号：
TQ174 [陶瓷工业]; TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The synergetic osteogenic effects of zirconium (Zr) and zinc (Zn) along with bioactive glasses (BGs) have been proposed for bone implantation. We incorporated Zn into Zr-modified 58S-BG (Zr content: 5 mol. %) and characterized the structural, morphological, biological, and antibacterial properties of the proposed composite using various methods. Energy-dispersive X-ray spectroscopy analysis showed the calcium to phosphate ratio of -1.68, after one week of conditioning in SBF. Biological assays also revealed a higher stimulating effect of the biomaterial composite on the proliferation and osteogenic response of osteoblast-like cells compared to only BGs. Antibacterial studies showed similar to 5-10% reduction in resistivity of methicillin-resistant Staphylococcus Aureus (MRSA) bacteria against the biomaterial composite in comparison to the control specimen. The incorporation of Zn led to potential outlooks for implantations instead of Zn-free specimens since they promoted the cell proliferation of MC3T3 cells as well as resistivity toward MRSA bacteria.
引用
收藏
页数：7
相关论文
共 84 条
[1]   Characterization and Elemental Quantification of Natural Hydroxyapatite Produced from Cow Bone [J].
Akindoyo, John O. ;
Ghazali, Suriati ;
Beg, Mohammad D. H. ;
Jeyaratnam, Nitthiyah .
CHEMICAL ENGINEERING & TECHNOLOGY, 2019, 42 (09) :1805-1815
[2]  
Aminitabar M., 2019, INT J CHEM MOL ENG, V13, P296
[3]   Mechanical properties and in vitro cellular behavior of zinc-containing nano-bioactive glass doped biphasic calcium phosphate bone substitutes [J].
Badr-Mohammadi, Mohammad-Reza ;
Hesaraki, Saeed ;
Zamanian, Ali .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2014, 25 (01) :185-197
[4]  
Balasubramanian P, 2015, BIOMEDICAL GLASSES, V7015, P1, DOI DOI 10.1515/BGLASS-2015-0006
[5]   Characterization of hydroxyapatite films obtained by pulsed-laser deposition on Ti and Ti-6AL-4v substrates [J].
Blind, O ;
Klein, LH ;
Dailey, B ;
Jordan, L .
DENTAL MATERIALS, 2005, 21 (11) :1017-1024
[6]   Polymer/bioactive glass nanocomposites for biomedical applications: A review [J].
Boccaccini, Aldo R. ;
Erol, Melek ;
Stark, Wendelin J. ;
Mohn, Dirk ;
Hong, Zhongkui ;
Mano, Joao F. .
COMPOSITES SCIENCE AND TECHNOLOGY, 2010, 70 (13) :1764-1776
[7]   The antibacterial effects of zinc ion migration from zinc-based glass polyalkenoate cements [J].
Boyd, D. ;
Li, H. ;
Tanner, D. A. ;
Towler, M. R. ;
Wall, J. G. .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2006, 17 (06) :489-494
[8]   Preliminary investigation of novel bone graft substitutes based on strontium-calcium-zinc-silicate glasses [J].
Boyd, D. ;
Carroll, G. ;
Towler, M. R. ;
Freeman, C. ;
Farthing, P. ;
Brook, I. M. .
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2009, 20 (01) :413-420
[9]   Zirconia in biomedical applications [J].
Chen, Yen-Wei ;
Moussi, Joelle ;
Drury, Jeanie L. ;
Wataha, John C. .
EXPERT REVIEW OF MEDICAL DEVICES, 2016, 13 (10) :945-963
[10]   Structure-dependence of anti-methicillin-resistant staphylococcus aureus (MRSA) activity on ZnO-containing bioglass [J].
Chen, Yu-Hsuan ;
Tseng, Sung-Pin ;
Wu, Shou-Mei ;
Shih, Chi-Jen .
JOURNAL OF ALLOYS AND COMPOUNDS, 2020, 848
123456789