New multifunctional complexes [Ru(κ3-L)(EPh3)2Cl]+ [E = P, As; L=2,4,6-tris(2-pyridyl)-1,3,5-triazine] containing both group v and polypyridyl ligands

Synthesis, structure, reactivity and enzyme inhibitory activity of the new cationic ruthenium complexes [Ru(kappa(3)-L)(EPh3)(2)Cl]BF4 [L = 2,4,6-tris(2-pyridyl)-1,3,5-triazine (tptz); E = P (1), As (2)] and their substitution products [Ru(kappa(3)- tptz)(PPh3)(dtc)]Cl (3), [Ru(kappa(3)-tptZ)(PPh3)(CN)(2)] (4), [Ru(kappa(3)-tptz)(AsPh3)(dtc)]BF4 (5), and [Ru(kappa(3)-tptz) (AsPh3)(CN)(2)] (6) are reported. The complexes were characterized by analytical and spectroscopic methods and the structures of the complexes 1, 2 and 3 determined by X-ray diffraction studies. C-(HX)-X-... (X = Cl, F and S), C-H(...)pi and pi-pi interactions were observed in these complexes. Further studies indicated that the complexes [Ru(kappa(3)-L)(EPh3)(2)Cl](+) could find application as precursors in the synthesis of other ruthenium complexes or as metallo-ligands. The complexes also interact with DNA, which was illustrated by absorption titration studies with CT-DNA and inhibition of topoisomerase If of the filarial parasite Setaria cervi. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)