Clonal spread and interspecies transmission of clinically relevant ESBL-producing Escherichia coli of ST410-another successful pandemic clone?

被引:105
作者
Schaufler, Katharina [1 ]
Semmler, Torsten [2 ]
Wieler, Lothar H. [3 ]
Woehrmann, Michael [1 ]
Baddam, Ramani [1 ,4 ]
Ahmed, Niyaz [4 ]
Mueller, Kerstin [5 ]
Kola, Axel [6 ]
Fruth, Angelika [7 ]
Ewers, Christa [8 ]
Guenther, Sebastian [1 ]
机构
[1] Free Univ Berlin, Fac Vet, Inst Microbiol & Epizoot, D-14163 Berlin, Germany
[2] Robert Koch Inst, NG Microbial Genom 1, D-13302 Berlin, Germany
[3] Robert Koch Inst, D-13302 Berlin, Germany
[4] Univ Hyderabad, Sch Life Sci, Dept Biotechnol & Bioinformat, Pathogen Biol Lab, Hyderabad 500046, Andhra Pradesh, India
[5] Free Univ Berlin, Fac Vet, Clin Small Anim, D-14163 Berlin, Germany
[6] Charite Univ Klinikum, Inst Hyg & Environm Med, D-12203 Berlin, Germany
[7] Robert Koch Inst, Ctr Salmonella & other Bacterial Enter Pathogens, Div Bacterial Infect & Natl Reference, Dept Infect Dis, D-38855 Wernigerode, Germany
[8] Univ Giessen, Fac Vet, Inst Hyg & Infect Dis Anim, D-35392 Giessen, Germany
关键词
ESBL-producing Escherichia coli; ST410; next-generation sequencing; 'one health' approach; SNP analysis; clone; SPECTRUM-BETA-LACTAMASE; ANTIBIOTIC-RESISTANCE GENES; MOLECULAR EPIDEMIOLOGY; CTX-M; DISSEMINATION; VIRULENCE; BACTERIA; SHV-12; ENTEROBACTERIACEAE; IDENTIFICATION;
D O I
10.1093/femsec/fiv155
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Clinically relevant extended-spectrum beta-lactamase (ESBL)-producing multi-resistant Escherichia coli have been on the rise for years. Initially restricted to mostly a clinical context, recent findings prove their prevalence in extraclinical settings independent of the original occurrence of antimicrobial resistance in the environment. To get further insights into the complex ecology of potentially clinically relevant ESBL-producing E. coli, 24 isolates from wild birds in Berlin, Germany, and 40 ESBL-producing human clinical E. coli isolates were comparatively analyzed. Isolates of ST410 occurred in both sample groups (six). In addition, three ESBL-producing E. coli isolates of ST410 from environmental dog feces and one clinical dog isolate were included. All 10 isolates were clonally analyzed showing almost identical macrorestriction patterns. They were chosen for whole-genome sequencing revealing that the whole-genome content of these 10 E. coli isolates showed a very high genetic similarity, differing by low numbers of single nucleotide polymorphisms only. This study gives initial evidence for a recent interspecies transmission of a new successful clone of ST410 E. coli between wildlife, humans, companion animals and the environment. The results underline the zoonotic potential of clinically relevant multi-resistant bacteria found in the environment as well as the mandatory nature of the 'One Health' approach.
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页数:9
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