miRNA Regulation Through Ligand Occupancy of a Nuclear Hormone Receptor

被引：4

作者：

Rougvie, Ann E. ^{[1
]}

机构：

[1] Univ Minnesota, Dept Genet Cell Biol & Dev, Minneapolis, MN 55455 USA

来源：

SCIENCE SIGNALING | 2009年 / 2卷 / 84期

关键词：

C-ELEGANS; CAENORHABDITIS-ELEGANS; REPRODUCTIVE DEVELOPMENT; TRANSCRIPTION FACTORS; DEVELOPMENTAL TIME; DAUER DIAPAUSE; MICRORNAS; EXPRESSION; LIN-28; GENES;

D O I：

10.1126/scisignal.284pe52

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) posttranscriptionally regulate gene expression, but the factors that direct transcription of miRNAs are not well characterized. Activation versus repression of key developmental miRNAs in Caenorhabditis elegans is directly mediated by ligand occupancy of a nuclear hormone receptor that acts to couple nutrient availability to developmental programs.

引用

页数：3

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