Synthesis of Spirocyclic Indolenines

被引：278

作者：

James, Michael J. ^{[1
]}

O'Brien, Peter ^{[1
]}

Taylor, Richard J. K. ^{[1
]}

Unsworth, William P. ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 09期

基金：

英国工程与自然科学研究理事会;

关键词：

3H-indoles; dearomatisation; indolenines; spirocycles; spiroindolenines; STEREOCONTROLLED TOTAL-SYNTHESIS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; PENTACYCLIC STRYCHNOS ALKALOIDS; COPPER-MEDIATED CONSTRUCTION; CATALYZED CASCADE REACTIONS; DIVERGENT TOTAL-SYNTHESIS; AZA-COPE REARRANGEMENTS; CONCISE TOTAL-SYNTHESIS; H COUPLING PROCESS; ASPIDOSPERMA ALKALOIDS;

D O I：

10.1002/chem.201503835

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This Review provides an in-depth account of the synthesis of spirocyclic indolenines. Over the last 77 years, a wide array of diverse synthetic methods has been developed in order to generate these synthetically useful and biologically important spirocyclic scaffolds. The main synthetic strategies discussed are grouped into three main categories, namely interrupted Fischer indolisations, dearomatisation reactions of indoles and condensation reactions. The historical background, common synthetic challenges, current state-of-the-art and future perspectives of this field are examined.

引用

页码：2856 / 2881

页数：26

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