Effects of deep brain stimulation of the peduncolopontine area on working memory tasks in patients with Parkinson's disease

被引：48

作者：

Costa, Alberto ^{[1
]}

Carlesimo, Giovanni Augusto ^{[1
,2
]}

Caltagirone, Carlo ^{[1
,2
]}

Mazzone, Paolo ^{[3
]}

Pierantozzi, Mariangela ^{[2
]}

Stefani, Alessandro ^{[2
]}

Peppe, Antonella ^{[1
]}

机构：

[1] Fdn IRCCS S Lucia, Lab Neurol Clin & Comportamentale, I-00179 Rome, Italy

[2] Univ Roma Tor Vergata, Neurol Clin, Rome, Italy

[3] ASL RMC, CTO, Rome, Italy

来源：

PARKINSONISM & RELATED DISORDERS | 2010年 / 16卷 / 01期

关键词：

Working memory; Parkinson's disease; Deep brain stimulation; PEDUNCULOPONTINE TEGMENTAL NUCLEUS; DOPAMINERGIC MODULATION; TARGET;

D O I：

10.1016/j.parkreldis.2009.05.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The present paper was aimed at investigating the effect of low-frequency electrical stimulation (25 Hz) of the peduncolopontine (PPN) area on working memory (WM) functioning in patients with Parkinson's disease (PD). Five PD patients who underwent simultaneous PPN area- and subthalamic nucleus-deep brain Stimulation (DBS) implantation participated in the study. PD patients Were evaluated in the morning at least 12 h after antiparkinsonian therapy withdrawal in two conditions: i) after continuous PPN area stimulation (Off Therapy/On PPN: "On" condition); ii) at least 120 min after PPN area had been switched "Off" (Off Ther/Off PPN: "Off'' condition). The experimental WM task consisted of an n-back paradigm with verbal and visual-object stimuli. PD patients showed a consistent response time decrease on both the Verbal and the visual-object tasks passing from the "Off'' to the "On" condition (p < 0.05). However, the accuracy Score did not significantly differ between the two experimental conditions. The present findings, although preliminary, suggest that PPN area stimulation facilitates the speed processing of information in the content of WM, possibly through the modulation of the attentional resources. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：64 / 67

页数：4

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