Synthesis and biological resolution of condensed bicyclic isoparaconic acid derivatives

被引:3
作者
Drioli, S [1 ]
Felluga, F [1 ]
Forzato, C [1 ]
Pitacco, G [1 ]
Valentin, E [1 ]
机构
[1] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 16期
关键词
D O I
10.1039/b001615m
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Kinetic resolution of chiral racemic (1R*,3aS*,7aS*)-hexahydro-2-oxobenzofuran-3-ylacetic acid ethyl ester was achieved by means of immobilized Lipozyme(R). At low conversion values, the (-)-acid was isolated with 84% ee, while at high conversion values the (+)-ester was obtained with 98% ee. Their configurations were determined by transformation of the acid into the corresponding alpha-methylene derivative of known absolute configuration.
引用
收藏
页码:2839 / 2842
页数:4
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