Mucosally transmitted feline immunodeficiency virus induces a CD8+ antiviral response that correlates with reduction of cell-associated virus

被引:54
作者
Bucci, JG
English, RV
Jordan, HL
Childers, TA
Tompkins, MB
Tompkins, WAF
机构
[1] N Carolina State Univ, Coll Vet Med, Dept Microbiol Pathol & Parasitol, Raleigh, NC 27606 USA
[2] Beth Israel Hosp, Div Viral Pathogenesis, Boston, MA 02215 USA
关键词
D O I
10.1086/513822
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Intravaginal inoculation of cats with feline immunodeficiency virus (FIV) results in acute systemic infection accompanied by a strong CD8(+) immune response that inhibits viral replication, CD8(+) anti-FIV activity, revealed by increased FIV replication in peripheral blood mononuclear cells (PBMC) depleted of CD8(+) lymphocytes, was detected by 6 weeks after inoculation and correlated with reduced PBMC-associated virus at 12, 16, and 32 weeks after inoculation, Some cats with strong CD8(+) anti-FIV activity during acute infection did not seroconvert and yielded no evidence of FIV infection at later times, These data suggest that CD8(+) immunity may play a major role in eliminating virus during primary transmucosal FIV infection and may down-regulate viral replication during asymptomatic infection.
引用
收藏
页码:18 / 25
页数:8
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